1-(Ethoxy-methyl-phosphinoyl)-cyclopropanecarboxylic acid | 131304-00-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(Ethoxy-methyl-phosphinoyl)-cyclopropanecarboxylic acid
• 英文别名: 1-[ethoxy(methyl)phosphoryl]cyclopropane-1-carboxylic acid
• CAS: 131304-00-2
• 化学式: C₇H₁₃O₄P
• 分子量: 192.152
• InChiKey: JMFIWHDWUNBUGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(Ethoxy-methyl-phosphinoyl)-cyclopropanecarboxylic acid 在 吡啶 、 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 (1-Diethylcarbamoyl-cyclopropyl)-methyl-phosphinic acid ethyl ester
  参考文献：
  名称：

  Some properties of 1-phosphorus(IV)-substituted cycloalkanecarboxylic acids and their derivatives

  摘要：

  An x-ray structural study of single crystals of 1-diphenylphosphinyl-cyclo-propane- and 1-diphenylphosphinylcyclobutanecarboxylic acids was conducted. 1-Phosphorylated cycloalkanecarboxylic acid amides were obtained from the corresponding acids by the reaction with thionyl chloride with subsequent treatment with primary and secondary amines. It was shown that the reaction of 1-phosphorylated 1-functional substituted cycloalkanes with trimethylbromosilane takes place with preservation of the cyclic structure and yields phosphoric acid silyl esters, and the corresponding cycloalkylphosphonic and cycloalkylphosphinic acids were synthesized by their hydrolysis in soft conditions.

  DOI：

  10.1007/bf00864348
• 作为产物：
  描述：

  1-Carboethoxy-1-O-ethylmethylphosphorylcyclopropane 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以30%的产率得到1-(Ethoxy-methyl-phosphinoyl)-cyclopropanecarboxylic acid
  参考文献：
  名称：

  Cycloalkylation of compounds in the series of phosphorus-substituted derivatives of acetic acid

  摘要：

  1-Phosphoryl-substituted cyclopropanes, cyclobutanes, and cyclopentanes were obtained by the reaction of phosphoryl-substituted esters and nitriles of acetic acid with alpha,omega-dihaloalkanes. The influence of the CH-acidity of the starting compounds and electrophilicity of the alkylating agent on the reaction rate was examined.

  DOI：

  10.1007/bf00961505

文献信息

• KAZAKOV, P. V.;ODINETS, I. L.;LARETINA, A. P.;SHCHERBINA, T. M.;PETROVSKI+, IZV. AN CCCP. CEP. XIM.,(1990) N, S. 1873-1880
  作者：KAZAKOV, P. V.、ODINETS, I. L.、LARETINA, A. P.、SHCHERBINA, T. M.、PETROVSKI+

  DOI：——

  日期：——