4-(2,3-Dichlorophenyl)-1,2,3,6-tetrahydropyridine | 187835-14-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,3-Dichlorophenyl)-1,2,3,6-tetrahydropyridine
• CAS: 187835-14-9
• 化学式: C₁₁H₁₁Cl₂N
• 分子量: 228.121
• InChiKey: NHULYHVMVISTGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(2,3-Dichlorophenyl)-1,2,3,6-tetrahydropyridine 、 盐酸 在 氧化铂 氢气 、 disodium;carbonate 、 乙酸乙酯 、 magnesium sulfate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 4-(2,3-dichlorophenyl)piperidine
  参考文献：
  名称：

  Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission

  摘要：

  本发明涉及具有治疗中枢神经系统疾病的作用的化合物，特别是新的4-(邻、间二取代苯基)-1-烷基哌啶，其中R1、R2和R3如所定义。

  公开号：

  US07851629B2
• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 4-(2,3-Dichlorophenyl)-1,2,3,6-tetrahydropyridine
  参考文献：
  名称：

  Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists

  摘要：

  Aryl-tetrahydropyridine derivatives were prepared and their PPAR alpha/gamma dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPAR alpha/gamma dual agonist with an EC50 of 1.73 and 0.64 mu M in hPPAR alpha and gamma, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.020

文献信息

• NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION
  申请人：Sonesson Clas

  公开号：US20070179185A1

  公开（公告）日：2007-08-02

  The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta-disubstituted phenyl)-1-alkypiperidines. wherein R1, R2, and R3 are as defined.

  本发明涉及对中枢神经系统障碍具有治疗效果的化合物，特别是新的4-(邻,间二取代苯基)-1-烷基哌啶，其中R1，R2和R3如定义。
• US7851629B2
  申请人：——

  公开号：US7851629B2

  公开（公告）日：2010-12-14
• [EN] NEW DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF DOPAMINE AND SEROTONIN NEUROTRANSMISSION<br/>[FR] NOUVEAUX PHENYLPIPERIDINES DISUBSTITUE UTILISES COMME MODULATEURS DE LA NEUROTRANSMISSION DE LA DOPAMINE ET DE LA SEROTONINE
  申请人：CARLSSON A RESEARCH AB

  公开号：WO2005121088A1

  公开（公告）日：2005-12-22

  The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta­ disubstituted phenyl)-1-alkypiperidines. (I) wherein R1, R2, and R3 are as defined.
• Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists
  作者：Eunkyung Kim、Chan Sun Park、Taedong Han、Myung-Ho Bae、Wonee Chong、Choong Hyun Lee、Young Ah Shin、Byung-Nak Ahn、Mi Kyung Kim、Chang Yell Shin、Moon Ho Son、Jin Kwan Kim、Ho Sang Moon、Hyun Joo Shim、Eun Jung Kim、Soon Hoe Kim、Joong In Lim、Chun Ho Lee

  DOI：10.1016/j.bmcl.2008.08.020

  日期：2008.9

  Aryl-tetrahydropyridine derivatives were prepared and their PPAR alpha/gamma dual agonistic activities were evaluated. Among them, compound (S)-5b was identified as a potent PPAR alpha/gamma dual agonist with an EC50 of 1.73 and 0.64 mu M in hPPAR alpha and gamma, respectively. In diabetic (db/db) mice, compound (S)-5b showed good glucose lowering efficacy and favorable pharmacokinetic properties. (C) 2008 Elsevier Ltd. All rights reserved.
• Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
  申请人：NSAB, Filial af Neurosearch Sweden AB, Sverige

  公开号：US07851629B2

  公开（公告）日：2010-12-14

  The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta-disubstituted phenyl)-1-alkypiperidines. wherein R1, R2, and R3 are as defined.

  本发明涉及具有治疗中枢神经系统疾病的作用的化合物，特别是新的4-(邻、间二取代苯基)-1-烷基哌啶，其中R1、R2和R3如所定义。