(E)-1-(Diphenyl-phosphinoyl)-2-methyl-hept-2-en-4-ol | 145653-17-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(Diphenyl-phosphinoyl)-2-methyl-hept-2-en-4-ol
• CAS: 145653-17-4
• 化学式: C₂₀H₂₅O₂P
• 分子量: 328.391
• InChiKey: WLFWAWWTEURDGG-BMRADRMJSA-N

物化性质

• 沸点：
  456.6±38.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (E)-1-(Diphenyl-phosphinoyl)-2-methyl-hept-2-en-4-ol 在 titanium(IV) isopropylate 、 叔丁基过氧化氢 、 L-(+)-酒石酸二异丙酯 、 4 A molecular sieve 作用下， 以 二氯甲烷 为溶剂， 反应 120.0h， 生成 (E)-(R)-1-(Diphenyl-phosphinoyl)-2-methyl-hept-2-en-4-ol 、 (R)-1-[(2S,3R)-3-(Diphenyl-phosphinoylmethyl)-3-methyl-oxiranyl]-butan-1-ol 、 (S)-1-[(2S,3R)-3-(Diphenyl-phosphinoylmethyl)-3-methyl-oxiranyl]-butan-1-ol 、 (R)-1-[(2R,3S)-3-(Diphenyl-phosphinoylmethyl)-3-methyl-oxiranyl]-butan-1-ol
  参考文献：
  名称：

  Asymmetric epoxidations and kinetic resolutions of δ-hydroxy allylic phosphine oxides

  摘要：

  Delta-Hydroxy allylic phosphine oxides 5 undergo asymmetric epoxidation to yield epoxy alcohols 6 with high enantio- and diastereoselectivity. Kinetic resolutions are also successful, even with a chiral centre remote from the allylic hydroxyl, if that chiral centre bears a diphenylphosphinoyl group. The diphenylphosphinoyl group then exerts a novel anti-directing effect on the epoxidation.

  DOI：

  10.1016/s0040-4039(00)60928-0