15-(tert-butyldimethyl)silyloxyprostaglandin A2 | 85453-77-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 15-(tert-butyldimethyl)silyloxyprostaglandin A2
• 英文别名: (Z)-7-[(1R,2S)-2-[(E,3S)-3-[tert-butyl(dimethyl)silyl]oxyoct-1-enyl]-5-oxocyclopent-3-en-1-yl]hept-5-enoic acid
• CAS: 85453-77-6
• 化学式: C₂₆H₄₄O₄Si
• 分子量: 448.718
• InChiKey: IRHLXUREBQCJEI-WIHBEWOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.09
• 重原子数：
  31
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  15-(tert-butyldimethyl)silyloxyprostaglandin A2 在 三氟化硫吗啉 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到15-(tert-butyldimethyl)silyloxyprostaglandin A2 fluoride
  参考文献：
  名称：

  Prostaglandin fluorides in synthesis of natural prostaglandin derivatives at carboxyl group

  摘要：

  Methods of synthesis of prostaglandin fluorides were developed and their properties were investigated. These compounds were shown to be convenient synthetic precursors for obtaining esters and amides of natural prostaglandins and their fluorodeoxy analogues.

  DOI：

  10.1134/s1068162009010142
• 作为产物：
  描述：

  15-(tert-butyldimethyl)silyloxyprostaglandin A2 tert-butyldimethylsilyl ester 在 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 0.03h， 以89%的产率得到15-(tert-butyldimethyl)silyloxyprostaglandin A2
  参考文献：
  名称：

  Prostaglandin fluorides in synthesis of natural prostaglandin derivatives at carboxyl group

  摘要：

  Methods of synthesis of prostaglandin fluorides were developed and their properties were investigated. These compounds were shown to be convenient synthetic precursors for obtaining esters and amides of natural prostaglandins and their fluorodeoxy analogues.

  DOI：

  10.1134/s1068162009010142