arginin monohydrate | 158435-28-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: arginin monohydrate
• 英文别名: 2-Amino-5-(diaminomethylideneazaniumyl)pentanoate;hydrate
• CAS: 158435-28-0
• 化学式: C₆H₁₄N₄O₂*H₂O
• 分子量: 192.218
• InChiKey: JVDHWXLTNDKLIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.63
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  133
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  arginin monohydrate 、 (S)-Pyrrolidine-1,2-dicarboxylic acid 1-butyl ester 2-(4-nitro-phenyl) ester 在 N-甲基吗啉 、 1-羟基苯并三唑 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 24.0h， 以85.5%的产率得到(S)-2-((S)-1-Carboxy-4-guanidino-butylcarbamoyl)-pyrrolidine-1-carboxylic acid butyl ester
  参考文献：
  名称：

  Unkovskii, V. I.; Vasil'eva, G. A.; Evstigneeva, R. P., Journal of general chemistry of the USSR, 1982, vol. 52, # 8, p. 1690 - 1693

  摘要：

  DOI：

文献信息

• [EN] METHODS FOR PRODUCTION OF HIGH CONCENTRATION OF ARGININE BICARBONATE SOLUTION AT HIGH PRESSUE<br/>[FR] PROCÉDÉS DE PRODUCTION À PRESSION ÉLEVÉE D'UNE SOLUTION DE BICARBONATE D'ARGININE À CONCENTRATION ÉLEVÉE
  申请人：COLGATE PALMOLIVE CO

  公开号：WO2011075422A1

  公开（公告）日：2011-06-23

  Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding subsequent portions of arginine to the resulting solution and further reacting with compressed carbon dioxide until a final solution containing in excess of 50% by weight are provided which include preparing an arginine solution by subjecting an arginine water slurry to elevated pressure and temperature and reacting the arginine solution with a source of carbon dioxide gas to form a solution comprising arginine and bicarbonate anion and recovering arginine bicarbonate from the solution.

  生产高浓度粉碳酸精氨酸溶液的方法包括：将含有第一部分精氨酸的粉状物与高压高温下的二氧化碳气体反应，向所得溶液中加入后续的精氨酸部分，并进一步使用压缩二氧化碳进行反应，直至得到含有超过50%重量的最终溶液；通过将精氨酸水浆置于高压高温下反应，将精氨酸溶液与二氧化碳气体反应形成含有精氨酸和碳酸氢根离子的溶液，并从中回收粉碳酸精氨酸。
• [EN] BASIC SALTS AND MONOHYDRATES OF CERTAIN ALPHA, BETA-PROPRIONIC ACID DERIVATIVE<br/>[FR] SELS DE BASE ET MONOHYDRATES DE CERTAINS DERIVES D'ACIDE ALPHA, BETA-PROPRIONIQUE
  申请人：REDDYS LAB LTD DR

  公开号：WO2006001795A1

  公开（公告）日：2006-01-05

  The invention provides novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid, including Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propilamino}phenyl] proprionic acid monohydrate, Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid, and (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid monohydrate. Various aspects and embodiments are included. Compositions containing novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid are also provided.

  本发明提供了(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸的新型盐，包括(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸精氨酸盐单水合物、(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸精氨酸盐和(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸单水合物。本发明还包括各种方面和实施例。本发明还提供了含有(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸新型盐的组合物。
• Basic salts and monohydrates of certain alpha, beta-propionic acid derivative
  申请人：Palle Venkata Raghavendra Charyulu

  公开号：US20050277693A1

  公开（公告）日：2005-12-15

  The invention provides novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid, including Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid monohydrate, Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl) propylamino} phenyl] propionic acid, and (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid monohydrate. Various aspects and embodiments are included. Compositions containing novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl) propylamino}phenyl] propionic acid are also provided.

  本发明提供了(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸的新型盐，包括(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸单水合物的精氨酸盐，(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸的精氨酸盐，以及(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸单水合物。包括各种方面和实施例。还提供了含有(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸新型盐的组合物。
• [EN] METHODS FOR PRODUCTION OF ARGININE BICARBONATE AT LOW PRESSURE<br/>[FR] PROCÉDÉ DE PRODUCTION DE BICARBONATE D'ARGININE À BASSE PRESSION
  申请人：COLGATE PALMOLIVE CO

  公开号：WO2011075472A1

  公开（公告）日：2011-06-23

  A method of producing arginine bicarbonate is provided including reacting an arginine slurry with a source of carbon dioxide gas under elevated temperature and low pressure to form a solution of at least 50% arginine bicarbonate, and recovering arginine bicarbonate from the solution.

  提供了一种生产精氨酸碳酸氢盐的方法，包括将精氨酸浆料与二氧化碳气体源在高温和低压下反应，形成至少50％精氨酸碳酸氢盐的溶液，并从溶液中回收精氨酸碳酸氢盐。
• METHODS FOR PRODUCTION OF HIGH CONCENTRATION OF ARGININE BICARBONATE SOLUTION AT HIGH PRESSURE
  申请人：Wu Donghui

  公开号：US20120296117A1

  公开（公告）日：2012-11-22

  Methods of producing arginine bicarbonate solutions in very high concentrations including reacting an arginine slurry containing a first portion of arginine with a source of carbon dioxide gas at elevated pressure and temperature, adding subsequent portions of arginine to the resulting solution and further reacting with compressed carbon dioxide until a final solution containing in excess of 50% by weight are provided which include preparing an arginine solution by subjecting an arginine water slurry to elevated pressure and temperature and reacting the arginine solution with a source of carbon dioxide gas to form a solution comprising arginine and bicarbonate anion and recovering arginine bicarbonate from the solution.

  生产高浓度精氨酸碳酸氢盐溶液的方法包括：将含有第一部分精氨酸的精氨酸浆料与高压和高温下的二氧化碳气体反应，向所得溶液中加入后续的精氨酸部分，并进一步与压缩的二氧化碳反应，直到提供含有超过50%重量的最终溶液；通过将精氨酸水浆料置于高压和高温下，使其形成精氨酸溶液，并将其与二氧化碳气体反应以形成包含精氨酸和碳酸氢根离子的溶液，并从中回收精氨酸碳酸氢盐。