terbium trinitrate trihydrate 18-crown ether-6 | 77885-70-2

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: terbium trinitrate trihydrate 18-crown ether-6
• 英文别名: terbium(III) nitrate * 18-crown-6 * 3H2O
• CAS: 77885-70-2
• 化学式: C₁₂H₂₄O₆*H₆N₃O₁₂Tb
• 分子量: 663.305
• InChiKey: UPUKSNGOKFVFPT-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  18-冠醚-6 、 terbium(III) nitrate hexahydrate 以 乙腈 为溶剂， 以86%的产率得到terbium trinitrate trihydrate 18-crown ether-6
  参考文献：
  名称：

  A novel antiamoebic agent against Acanthamoeba sp. — A causative agent for eye keratitis infection

  摘要：

  The terbium trinitrate.trihydrate.18-crown ether-6, Tb(NO3)(3)(OH2)(3)center dot(18C6) complex has been characterized by elemental analysis, photoluminescence and single X-ray diffraction. The IC50 values were determined based on MTT assay while light and fluorescence microscopy imaging were employed to evaluate the cellular morphological changes. Alkaline comet assay was performed to analyze the DNA damage. The photoluminescence spectrum of the Tb complex excited at 325 nm displayed seven luminescence peaks corresponding to the D-5(4) -> F-7(0, 1, 2, 3, 4, 5, 6) transitions. The cytotoxicity and genotoxicity studies indicated that the Tb(NO3)(3)(OH2)(3)center dot(18C6) complex and its salt form as well as the 18C6 molecule have excellent antiamoebic activity with very low IC50 values are 7, 2.6 and 1.2 mu g/mL, respectively, with significant decrease (p < 0.05) in Acanthamoeba viability when the concentration was increased from 0 to 30 mu g/mL. The mode of cell death in Acanthamoeba cells following treatment with the Tb complex was apoptosis. This is in contrast to the Tb(NO3)(3)center dot 6H(2)O salt- and 18C6 molecule-treated Acanthamoeba, which exhibited necrotic type cells. The percentage of DNA damage following treatment with all the compounds at the IC25 values showed high percentage of type 1 with the % nuclei damage are 14.15 +/- 2.4; 46.00 +/- 4.2; 36.36 +/- 2.4; 45.16 +/- 0.6%, respectively for untreated, treated with Tb complex, Tb salt and 18C6 molecule. The work features promising potential of Tb(NO3)(3)(OH2)(3)center dot(18C6) complex as anti-amoebic agent, representing a therapeutic option for Acanthamoeba keratitis infection. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2015.09.021

文献信息

• Complexes of lanthanide ions with the crown ether 1,4,7,10,13,16-hexaoxacyclo-octadecane
  作者：J. D. Julius Backer-Dirks、James E. Cooke、Anita M. R. Galas、Joginder S. Ghotra、Colin J. Gray、F. Alan Hart、Michael B. Hursthouse

  DOI：10.1039/dt9800002191

  日期：——

  The title crown ether forms three types of compound with lanthanide ions, [M(NO3)3(crown)](M = La—Nd), M4(NO3)12(crown)3(M = La—Gd), and [M(NO3)3(OH2)3]·crown (M =Gd—Lu). Crystal structures of the first and third types have been determined by X-ray diffraction. The complex [La(NO3)3(crown)] is orthorhombic, space group Pbca, with a= 12.249, b= 15.618, c= 21.852 Å, and Z= 8. Least-squares refinement

  标题冠醚与镧系元素离子形成三种类型的化合物：[M（NO 3）3（冠）]（M = La-Nd），M 4（NO 3）12（冠）3（M = La-Gd）和[M（NO 3）3（OH 2）3 ]·冠（M = Gd-Lu）。第一和第三类型的晶体结构已经通过X射线衍射确定。复合物[La（NO 3）3（冠）]是正交的，空间群Pbca，a = 12.249，b = 15.618，c = 21.852Å，Z=8。使用3 607个观测到的[ I >1.5σ（I）]强度数据进行最小二乘法精炼，得出R = 0.039 9.镧配位包括六个冠氧[La–O = 2.627–2.771（3） Å]和来自三个双齿硝酸盐中的每一个的两个氧[La–O = 2.644–2.675（3）Å]。复杂的[Gd（NO 3）3（OH 2）3 ]·冠也是正交的，空间群可能是Pn 2 1 a，a = 15.259，b = 14.302，c = 11
• Nikulina, L. D.; Martynova, T. N.; Potapova, O. G., Russian Journal of Inorganic Chemistry, 1989, vol. 34, p. 822 - 826
  作者：Nikulina, L. D.、Martynova, T. N.、Potapova, O. G.、Polyanskaya, T. M.

  DOI：——

  日期：——