tianeptine hemisulfate | 2093109-76-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: tianeptine hemisulfate
• 英文别名: Tianeptine sulfate；7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid;sulfuric acid
• CAS: 2093109-76-1
• 化学式: C₂₁H₂₅ClN₂O₄S*H₂O₄S
• 分子量: 535.039
• InChiKey: SKEOVGLOOAJSTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.54
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  178
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  (+)-噻奈普汀单钠盐 在 溶剂黄146 、 硫酸 作用下， 以 水 为溶剂， 反应 5.38h， 生成 tianeptine hemisulfate
  参考文献：
  名称：

  TIANEPTINE SULFATE SALT FORMS AND METHODS OF MAKING AND USING THE SAME

  摘要：

  本文披露了一种具有改进性能的替格瑞派钠的新型硫酸盐。本文还描述了包含替格瑞派钠硫酸盐的新型药物组合物，制备方法以及相关治疗方法。

  公开号：

  US20100112051A1

文献信息

• Dietary supplement
  申请人：Morrissette James Peter

  公开号：US10624902B1

  公开（公告）日：2020-04-21

  A dietary supplement can consisting of tianeptine and sakae naa. The supplement can optionally additionally consist of stearate and silicate. The supplement can further consist of kava. The supplement can also consist of tianeptine, CDP Choline, and Alpha GPC. A method of forming a dietary supplement can include creating a composition of matter, and filling a capsule with the composition of matter to form the dietary supplement.

  一种膳食补充剂可由噻奈普汀和卡瓦胡椒组成，也可选择由硬脂酸盐和硅酸盐组成。补充剂还可以由卡瓦组成。该营养补充剂还可由天奈肽、CDP 胆碱和 Alpha GPC 组成。形成膳食补充剂的方法可包括制造物质组合物，并用物质组合物填充胶囊以形成膳食补充剂。
• TRICYCLIC DIBENZOTHIAZEPINE TYPE COMPOUNDS FOR USE IN THE THERAPY OF CDKL5 DISORDER
  申请人：Healx Limited

  公开号：EP3356337A1

  公开（公告）日：2018-08-08
• COMBINATION OF M-OPIOID RECEPTOR (MOR) MODULATORS FOR PREVENTING AND TREATING PAIN, SUICIDALITY AND MENTAL DISORDERS
  申请人：Hadasit Medical Research Services and Development Ltd.

  公开号：EP3873447A1

  公开（公告）日：2021-09-08
• MAINTENANCE THERAPY USING TIANEPTINE
  申请人：GENOMIND, Inc.

  公开号：US20180042936A1

  公开（公告）日：2018-02-15

  The present application provides a method for treating treatment-resistant depression in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of tianeptine, subsequent to a ketamine treatment; also provided is a method of treating suicidal ideation (SI), post-traumatic stress disorder (PTSD), mild cognitive impairment (MCI) or pre-dementia co-morbid with symptoms of depression; and further provided is maintenance therapy for depression remission.
• DIETARY SUPPLEMENT
  申请人：MORRISSETTE JAMES PETER

  公开号：US20200206240A1

  公开（公告）日：2020-07-02

  A method of forming a dietary supplement can include steps of creating a composition of matter comprising tianeptine, sakae naa, and optionally, at least one of kava, CDP Choline, and Alpha GPC; and providing the composition of matter in a liquid or solid form. The ingredient of tianeptine can be tianeptine sodium, tianeptine free acid, or both. Providing the composition of matter can include filling a container with the composition of matter.