(5R^*,5aS^*,9aR^*,10R^*)-N-acetyl-5a,6,7,8,9,9a,10,11-octahydro-5-methyl-5H-dibenzocyclohepten-5,10-imine | 125024-01-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (5R^*,5aS^*,9aR^*,10R^*)-N-acetyl-5a,6,7,8,9,9a,10,11-octahydro-5-methyl-5H-dibenzocyclohepten-5,10-imine
• CAS: 125024-01-3
• 化学式: C₁₈H₂₃NO
• 分子量: 269.387
• InChiKey: OUJAHHXQNCFNNN-XOYOTBSWSA-N

反应信息

• 作为产物：
  描述：

  (+/-) 10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine acetate salt 在 Rh/Al₂O₃ 氢气 作用下， 以 乙醇 为溶剂， 60.0 ℃ 、10.34 MPa 条件下， 反应 18.0h， 以4.2%的产率得到(4aR^*,5S^*,10R^*,11aR^*)-1,2,3,4,4a,10,11,11a-octahydro-5-methyl-5H-dibenzocyclohepten-5,10-imine
  参考文献：
  名称：

  Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801)

  摘要：

  Several hydrogenated derivatives of the potent NMDA antagonist 1 have been prepared and evaluated as competitive inhibitors of [3H]-1 binding. These compounds were also tested for their ability to act as noncompetitive antagonists of NMDA in vitro. These studies indicate that two aromatic rings are not strictly required for high-affinity binding or NMDA antagonism.

  DOI：

  10.1021/jm00165a026