N-(2,2-dimethoxyethyl)octanamide | 1343573-61-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(2,2-dimethoxyethyl)octanamide
• CAS: 1343573-61-4
• 化学式: C₁₂H₂₅NO₃
• 分子量: 231.335
• InChiKey: OCCYUXPIDBUULG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(2,2-dimethoxyethyl)octanamide 生成 N-octanoylglycinal
  参考文献：
  名称：

  N-Acylethanolamines as novel alcohol dehydrogenase 3 substrates

  摘要：

  N-Acylethanolamines (NAEs) are members of the fatty acid amide family. The NAEs have been proposed to serve as metabolic precursors to N-acylglycines (NAGS). The sequential oxidation of the NAEs by an alcohol dehydrogenase and an aldehyde dehydrogenase would yield the N-acylglycinals and/or the NAGs. Alcohol dehydrogenase 3 (ADH3) is one enzyme that might catalyze this reaction. To define a potential role for ADH3 in NAE catabolism, we synthesized a set of NAEs and evaluated these as ADH3 substrates. NAEs were oxidized by ADH3, yielding the N-acylglycinals as the product. The (V/K)(app) values for the NAEs included here were low relative to cinnamyl alcohol. Our data show that the NAEs can serve as alcohol dehydrogenase substrates. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.abb.2010.12.002
• 作为产物：
  描述：

  氨基乙醛缩二乙醇 、 辛酰氯 生成 N-(2,2-dimethoxyethyl)octanamide
  参考文献：
  名称：

  N-Acylethanolamines as novel alcohol dehydrogenase 3 substrates

  摘要：

  N-Acylethanolamines (NAEs) are members of the fatty acid amide family. The NAEs have been proposed to serve as metabolic precursors to N-acylglycines (NAGS). The sequential oxidation of the NAEs by an alcohol dehydrogenase and an aldehyde dehydrogenase would yield the N-acylglycinals and/or the NAGs. Alcohol dehydrogenase 3 (ADH3) is one enzyme that might catalyze this reaction. To define a potential role for ADH3 in NAE catabolism, we synthesized a set of NAEs and evaluated these as ADH3 substrates. NAEs were oxidized by ADH3, yielding the N-acylglycinals as the product. The (V/K)(app) values for the NAEs included here were low relative to cinnamyl alcohol. Our data show that the NAEs can serve as alcohol dehydrogenase substrates. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.abb.2010.12.002

文献信息

• N-Acylethanolamines as novel alcohol dehydrogenase 3 substrates
  作者：Milena Ivkovic、Daniel R. Dempsey、Sumit Handa、Joshua H. Hilton、Edward W. Lowe、David J. Merkler

  DOI：10.1016/j.abb.2010.12.002

  日期：2011.2

  N-Acylethanolamines (NAEs) are members of the fatty acid amide family. The NAEs have been proposed to serve as metabolic precursors to N-acylglycines (NAGS). The sequential oxidation of the NAEs by an alcohol dehydrogenase and an aldehyde dehydrogenase would yield the N-acylglycinals and/or the NAGs. Alcohol dehydrogenase 3 (ADH3) is one enzyme that might catalyze this reaction. To define a potential role for ADH3 in NAE catabolism, we synthesized a set of NAEs and evaluated these as ADH3 substrates. NAEs were oxidized by ADH3, yielding the N-acylglycinals as the product. The (V/K)(app) values for the NAEs included here were low relative to cinnamyl alcohol. Our data show that the NAEs can serve as alcohol dehydrogenase substrates. (C) 2010 Elsevier Inc. All rights reserved.