N-δ-tert-butoxycarbonyl-L-ornithine methyl amide | 178932-85-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-δ-tert-butoxycarbonyl-L-ornithine methyl amide
• 英文别名: (2S)-N-Methyl-2-amino-5-(tert-butyloxycarbonylamino)pentanamide；tert-butyl N-[(4S)-4-amino-5-(methylamino)-5-oxopentyl]carbamate
• CAS: 178932-85-9
• 化学式: C₁₁H₂₃N₃O₃
• 分子量: 245.322
• InChiKey: HJXFQERIKCEAJI-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  93.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-δ-tert-butoxycarbonyl-L-ornithine methyl amide 在 sodium hydride 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  P1, P2′-Linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

  摘要：

  A novel series of 13- and 14-membered macrocyclic amines was developed by linking the P-1, and P-2, groups. The synthesis entails stereoselective Frater alkylation to install the anti-succinate configuration and macrocyclic amination via nucleophilic displacement. This strategy resulted in a new class of conformationally constrained inhibitors that are potent ind selective for MMP-8 and 9 over MMP-1 and 3. (C) 1999 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00215-2
• 作为产物：
  描述：

  methylamide of N^α-4-toluenesulfonyl-N^δ-tert-butyloxycarbonylornithine 在 calcium 作用下， 以 氨 为溶剂， 反应 0.02h， 以85%的产率得到N-δ-tert-butoxycarbonyl-L-ornithine methyl amide
  参考文献：
  名称：

  Hlavacek, Jan; Fric, Ivo; Budesinsky, Milos, Collection of Czechoslovak Chemical Communications, 1988, vol. 53, # 11A, p. 2473 - 2494

  摘要：

  DOI：

文献信息

• Stereochemically pure α-trifluoromethyl-malic hydroxamates: synthesis and evaluation as inhibitors of matrix metalloproteinases
  作者：Margherita Moreno、Monica Sani、Guido Raos、Stefano V. Meille、Dorina Belotti、Raffaella Giavazzi、Stefano Bellosta、Alessandro Volonterio、Matteo Zanda

  DOI：10.1016/j.tet.2006.08.036

  日期：2006.10

  The synthesis of trifluoromethyl (Tfm) analogs of known nanomolar matrix metalloproteinases (MMPs) inhibitors has been performed. The synthetic protocol is based on a moderately stereoselective aldol reaction of trifluoropyruvate with an N-acyl-oxazolidin-2-thione for the construction of the core α-Tfm-malic unit. Both the diastereomeric forms of the target α-Tfm-malic hydroxamates showed micromolar

  已进行了已知的纳摩尔基质金属蛋白酶（MMPs）抑制剂的三氟甲基（Tfm）类似物的合成。合成规程基于三氟丙酮酸与N-酰基-恶唑烷丁-2-硫酮的中等立体选择性醛醇缩合反应，用于构建核心α-Tfm-苹果酸单元。根据酶谱测试，目标α-Tfm-苹果酸异羟肟酸酯的两种非对映体形式均表现出对MMP-2和9的微摩尔抑制潜能，相对于母体未氟化化合物而言，显着下降。我们还报告了一些分子建模结果，为实验结果提供了理论依据。
• Macrocyclic broad spectrum antibiotics
  申请人：RQX PHARMACEUTICALS, INC.

  公开号：US11072635B2

  公开（公告）日：2021-07-27

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

  本文提供的是抗菌化合物，其中的化合物在某些实施方案中具有广谱生物活性。在不同的实施方案中，这些化合物通过抑制细菌 1 型信号肽酶（SpsB）发挥作用，SpsB 是细菌中的一种重要蛋白质。还提供了使用本文所述化合物进行治疗的药物组合物和方法。
• Antitumor Imidazotetrazines. 41. Conjugation of the Antitumor Agents Mitozolomide and Temozolomide to Peptides and Lexitropsins Bearing DNA Major and Minor Groove-Binding Structural Motifs
  作者：Jill Arrowsmith、Sharon A. Jennings、Alan S. Clark、Malcolm F. G. Stevens

  DOI：10.1021/jm020936d

  日期：2002.12.1

  Carboxylic acids derived from the amido groups of the antitumor agents mitozolomide and temozolomide have been conjugated to simple amino acids and peptides by carbodiimide coupling. Solid-state peptide synthesis has been applied to link the acids to DNA major groove-binding peptidic motifs known to adopt alpha-helical conformations. Attachment of the acids to pyrrole and imidazole polyamidic lexitropsins gave a series of potential DNA minor groove- binding ligands. In vitro biological evaluation of a limited number of these novel conjugates failed to demonstrate any enhanced growth-inhibitory activity compared to the unconjugated drugs; sites of alkylation at tracts of multiple guanines were also unaffected. Attachment of additional residues at C-8 of the imidazotetrazines did not perturb the chemistry of activation of the bicyclic nucleus, and biological sequelae can be rationalized by invoking the liberation of a common, diffusible, reactive chemical intermediate, the methanediazonium ion.
• Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases
  作者：Irina C. Jacobson、Prabhakar G. Reddy、Zelda R. Wasserman、Karl D. Hardman、Maryanne B. Covington、Elizabeth C. Arner、Robert A. Copeland、Carl P. Decicco、Ronald L. Magolda

  DOI：10.1016/s0960-894x(98)00125-5

  日期：1998.4

  Examination of the S1 area of the active site of pro-stromelysin has led us to the design of novel and potent inhibitors of matrix metalloproteinases containing constrained quaternary-hydroxy group at pi. The synthesis and biological activity of these compounds with variations at P1', P2', and P3' will be described. (C) 1998 The DuPont Merck Pharmaceutical Company. Published by Elsevier Science Ltd. All rights reserved.
• Synthesis and evaluation of stereopure α-trifluoromethyl-malic hydroxamates as inhibitors of matrix metalloproteinases
  作者：Monica Sani、Dorina Belotti、Raffaella Giavazzi、Walter Panzeri、Alessandro Volonterio、Matteo Zanda

  DOI：10.1016/j.tetlet.2003.12.131

  日期：2004.2

  The total synthesis of trifluoromethyl (Tfm) analogs of known nanomolar matrix metalloprotein ases (MMPs) inhibitors has been performed. The synthetic protocol is based on a moderately stereoselective aldol reaction of trifluoropyruvate with an N-acyl-oxazolidin-2-thione for the construction of the core alpha-Tfm-malic unit. Both the diastereomeric forms of the target alpha-Tfm-malic hydroxamates showed micromolar inhibitory potency toward MMP-2 and 9, with a substantial drop with respect to the parent unfluorinated compounds. (C) 2004 Elsevier Ltd. All rights reserved.