[(2S,3R,4S,5S,6S)-3,5-diacetyloxy-2-prop-2-enoxy-6-[[4-[[(2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-prop-2-enoxyoxane-2-carbonyl]amino]phenyl]carbamoyl]oxan-4-yl] acetate | 799280-68-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(2S,3R,4S,5S,6S)-3,5-diacetyloxy-2-prop-2-enoxy-6-[[4-[[(2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-prop-2-enoxyoxane-2-carbonyl]amino]phenyl]carbamoyl]oxan-4-yl] acetate
• CAS: 799280-68-5
• 化学式: C₃₆H₄₄N₂O₁₈
• 分子量: 792.748
• InChiKey: YNXYIVHQYGIXKZ-OSYJMSNRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  56
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  253
• 氢给体数：
  2
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  [(2S,3R,4S,5S,6S)-3,5-diacetyloxy-2-prop-2-enoxy-6-[[4-[[(2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-prop-2-enoxyoxane-2-carbonyl]amino]phenyl]carbamoyl]oxan-4-yl] acetate 生成
  参考文献：
  名称：

  Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a β-cyclodextrin mimic

  摘要：

  Rigid macrocyclic scaffolds based on carbohydrates have potential for the display of recognition groups with defined 3D structure and may have application in bioorganic and supramolecular chemistry. A series of water soluble macrocyclic structures containing two saccharide units was synthesised by ring closing metathesis of allyl and pentenyl glycosides derived from glucuronic acid. The 3D structure of the constrained systems was explored by NMR and computational methods. CD spectra were also recorded. On the basis of experimental observations we suggest that the carbohydrate presentation is constrained into a U-shape for the smaller ring size but can access an S-shape arrangement in the larger macrocycle. As an extension it is shown that the larger macrocycle displayed phenomena similar to beta-cyclodextrin (beta-CD). The binding of 8-anilino-1-naphthalenesulfonate (ANS) to beta-CD is detectable by reversal of quenching of the ANS emission spectrum and a similar reversal of quenching was observed when this macrocycle was added to a solution of ANS; this was further supported by NMR. Furthermore molecular modelling suggests that the macrocyclic scaffolding has potential for the development of peptidomimetics. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.020
• 作为产物：
  描述：

  allyl 2,3,4-tri-O-acetyl-α-D-glucopyranosiduronic acid 在 草酰氯 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 [(2S,3R,4S,5S,6S)-3,5-diacetyloxy-2-prop-2-enoxy-6-[[4-[[(2S,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-prop-2-enoxyoxane-2-carbonyl]amino]phenyl]carbamoyl]oxan-4-yl] acetate
  参考文献：
  名称：

  Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a β-cyclodextrin mimic

  摘要：

  Rigid macrocyclic scaffolds based on carbohydrates have potential for the display of recognition groups with defined 3D structure and may have application in bioorganic and supramolecular chemistry. A series of water soluble macrocyclic structures containing two saccharide units was synthesised by ring closing metathesis of allyl and pentenyl glycosides derived from glucuronic acid. The 3D structure of the constrained systems was explored by NMR and computational methods. CD spectra were also recorded. On the basis of experimental observations we suggest that the carbohydrate presentation is constrained into a U-shape for the smaller ring size but can access an S-shape arrangement in the larger macrocycle. As an extension it is shown that the larger macrocycle displayed phenomena similar to beta-cyclodextrin (beta-CD). The binding of 8-anilino-1-naphthalenesulfonate (ANS) to beta-CD is detectable by reversal of quenching of the ANS emission spectrum and a similar reversal of quenching was observed when this macrocycle was added to a solution of ANS; this was further supported by NMR. Furthermore molecular modelling suggests that the macrocyclic scaffolding has potential for the development of peptidomimetics. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.020

文献信息

• Metathesis of Structurally Preorganized Bivalent Carbohydrates. Synthesis of Macrocyclic and Oligomeric Scaffolds
  作者：Trinidad Velasco-Torrijos、Paul V. Murphy

  DOI：10.1021/ol0484254

  日期：2004.10.1

  [GRAPHICS]Bivalent carbohydrate substrates for metathesis were synthesized from glucuronic acid and phenylene-1,4-diamine. The substrate secondary structure depends on whether secondary or tertiary amides are present, and this influences the course of the metathesis reaction leading to novel multivalent scaffolding. Molecular modeling suggests that a very rigid macrocyclic scaffold has potential for the development of alpha-helix peptidomimetics.