4,4,5,5,6,6,6-七氟-3-羟基己酸 | 356-31-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 4,4,5,5,6,6,6-七氟-3-羟基己酸
• 英文名称: 4,4,5,5,6,6,6-heptafluoro-3-hydroxy-hexanoic acid
• 英文别名: 4,4,5,5,6,6,6-Heptafluor-3-hydroxy-hexansaeure；4,4,5,5,6,6,6-Heptafluoro-3-hydroxyhexanoic acid
• CAS: 356-31-0
• 化学式: C₆H₅F₇O₃
• 分子量: 258.093
• InChiKey: MQQQKVVUUWEUMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  乙醇 、 4,4,5,5,6,6,6-七氟-3-羟基己酸 在 盐酸 作用下， 生成 4,4,5,5,6,6,6-heptafluoro-3-hydroxy-hexanoic acid ethyl ester
  参考文献：
  名称：

  Perfluoroalkyl-substituted Dicarboxylic Acids and Derivatives^1,2

  摘要：

  DOI：

  10.1021/ja01566a082
• 作为产物：
  描述：

  4,4,5,5,6,6,6-heptafluoro-3-hydroxy-hexanoic acid ethyl ester 在 sodium hydroxide 作用下， 生成 4,4,5,5,6,6,6-七氟-3-羟基己酸
  参考文献：
  名称：

  One haemodialysis unit's experience of hepatitis B

  摘要：

  SummaryHaemodialysis patients are at high risk of contracting Hepatitis B Virus (HBV). This blood borne virus has been responsible for many critical incidents within haemodialysis units around the world. This paper seeks to explore one such outbreak and at the same time look more closely at HBV and connected issues. The incident discussed occurred within a haemodialysis unit situated in the Northwest of England. This paper is presented as a case study. When HBV was detected in a previously HBV negative patient a crisis management team moved quickly to contain any possible outbreak and sought to discover the origin of the infection. An outline of the personal and financial cost to the organisation, what lessons have been learnt and why recommendations have been made to immunise the local dialysis population again HBV will be presented.

  DOI：

  10.1111/j.1755-6686.2000.tb00071.x

文献信息

• Perfluoroalkyl-substituted Dicarboxylic Acids and Derivatives^1,2
  作者：E. T. McBee、C. W. Roberts、Gordon Wilson

  DOI：10.1021/ja01566a082

  日期：1957.5
• One haemodialysis unit's experience of hepatitis B
  作者：A Balshaw、J Casey

  DOI：10.1111/j.1755-6686.2000.tb00071.x

  日期：2000.1.3

  SummaryHaemodialysis patients are at high risk of contracting Hepatitis B Virus (HBV). This blood borne virus has been responsible for many critical incidents within haemodialysis units around the world. This paper seeks to explore one such outbreak and at the same time look more closely at HBV and connected issues. The incident discussed occurred within a haemodialysis unit situated in the Northwest of England. This paper is presented as a case study. When HBV was detected in a previously HBV negative patient a crisis management team moved quickly to contain any possible outbreak and sought to discover the origin of the infection. An outline of the personal and financial cost to the organisation, what lessons have been learnt and why recommendations have been made to immunise the local dialysis population again HBV will be presented.