(9-methyl-9H-carbazole-3,6-diyl)bis((5-bromobenzofuran-2-yl)methanone) | 1369796-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (9-methyl-9H-carbazole-3,6-diyl)bis((5-bromobenzofuran-2-yl)methanone)
• 英文别名: [6-(5-Bromo-1-benzofuran-2-carbonyl)-9-methylcarbazol-3-yl]-(5-bromo-1-benzofuran-2-yl)methanone
• CAS: 1369796-98-4
• 化学式: C₃₁H₁₇Br₂NO₄
• 分子量: 627.288
• InChiKey: MQKSIJGORAZHQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  65.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基咔唑 在 aluminum (III) chloride 、 potassium carbonate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 52.0h， 生成 (9-methyl-9H-carbazole-3,6-diyl)bis((5-bromobenzofuran-2-yl)methanone)
  参考文献：
  名称：

  PEG-400-Promoted and Ultrasound Assisted Rap-Stoermer Reaction for Efficient Synthesis of Benzofuran-2-yl(carbazolyl)methanone Derivatives

  摘要：

  A facile synthesis of hitherto unreported (9-methyl-9H-carbazole-3,6-diyl)bis(benzofuran-2-yl-methanone)s (3a-t) is described, featuring the PEG-400-promoted and ultrasound-assisted Rap-Stoermer reaction of 3,6-dichloroacetyl-9-methyl-9H-carbazole (1) with a variety of salicylaldehydes as well as 2-hydroxy-1-naphthaldehyde (2) in the presence of K2CO3 as the base in acetonitrile. This procedure offers easy access to benzofuran-2-yl(carbazolyl)-methanone derivatives in short reaction time and the products are achieved in good yields.

  DOI：

  10.3987/com-11-12385

文献信息

• PEG-400-Promoted and Ultrasound Assisted Rap-Stoermer Reaction for Efficient Synthesis of Benzofuran-2-yl(carbazolyl)methanone Derivatives
  作者：Wentao Gao、Yan Yan、Yang Li

  DOI：10.3987/com-11-12385

  日期：——

  A facile synthesis of hitherto unreported (9-methyl-9H-carbazole-3,6-diyl)bis(benzofuran-2-yl-methanone)s (3a-t) is described, featuring the PEG-400-promoted and ultrasound-assisted Rap-Stoermer reaction of 3,6-dichloroacetyl-9-methyl-9H-carbazole (1) with a variety of salicylaldehydes as well as 2-hydroxy-1-naphthaldehyde (2) in the presence of K2CO3 as the base in acetonitrile. This procedure offers easy access to benzofuran-2-yl(carbazolyl)-methanone derivatives in short reaction time and the products are achieved in good yields.