Methyl 4-amino-3-methoxyiminomethylbenzoate | 201932-94-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 4-amino-3-methoxyiminomethylbenzoate
• 英文别名: methyl 4-amino-3-(methoxyiminomethyl)benzoate
• CAS: 201932-94-7
• 化学式: C₁₀H₁₂N₂O₃
• 分子量: 208.21
• InChiKey: ZZRWDCSPDWXJKU-UHFFFAOYSA-N

物化性质

• 沸点：
  375.4±52.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  溶剂黄146 、 Methyl 3-methoxyiminomethyl-4-nitrobenzoate 在 铁粉 水 、 乙醚 、 碳酸氢钠 、 Brine 、 magnesium sulfate 作用下， 以 乙酸乙酯 为溶剂， 反应 0.5h， 以yielding 130 g of the expected methyl 4-amino-3-methoxyiminomethylbenzoate的产率得到Methyl 4-amino-3-methoxyiminomethylbenzoate
  参考文献：
  名称：

  Methods for controlling algae

  摘要：

  本文介绍了一种控制藻类和海洋污垢生物的方法。该方法使用N-乙酰基苯甲酰胺化合物，以有效的剂量杀死或抑制藻类或污垢生物的生长。

  公开号：

  US05981435A1

文献信息

• Method for treating protozoal infections
  申请人：Rohm and Haas Company

  公开号：US06107316A1

  公开（公告）日：2000-08-22

  A method for treating protozoal infections is described. The method employs N-acetonylbenzamide compounds provided in an effective amount to inhibit the growth of protozoans. The compounds are useful in controlling such protozoan parasites as Giardia lamblia, Leishmania major, Entamoeba histolytica, Cryptosporidium parvum, Toxoplasma gondii and microsporidia.

  本文描述了一种治疗原虫感染的方法。该方法使用N-乙酰基苯甲酰胺类化合物，以有效的剂量抑制原虫的生长。这些化合物对于控制Giardia lamblia、Leishmania major、Entamoeba histolytica、Cryptosporidium parvum、Toxoplasma gondii和微孢子虫等原虫寄生虫非常有用。
• Process for the manufacture of acetonylbenzamides
  申请人：Rohm and Haas Company

  公开号：US05874466A1

  公开（公告）日：1999-02-23

  Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.

  通过胺和酰氯的反应提供了制备丙酮基苯甲酰胺的新途径。还揭示了制造丙酮基苯甲酰胺所使用的各种中间体的新途径。
• Fungicidically active N-acetonylbenzamide compounds
  申请人：Rohm and Haas Company

  公开号：US05929098A1

  公开（公告）日：1999-07-27

  Novel N-acetonylbenzamides are disclosed. These compounds are useful in controlling phytopathogenic fungi.

  本发明揭示了新型的N-乙酰基苯甲酰胺化合物。这些化合物对于控制植物病原真菌具有实用性。
• Use of certain amides as probes for detection of antitubulin activity and resistance monitoring
  申请人：Dow AgroSciences LLC

  公开号：US06500405B1

  公开（公告）日：2002-12-31

  This invention relates to methods for screening compounds for antitubulin activity, evaluation of cells for sensitivity to antitubulin drugs, resistance monitoring and quantifying tubulin using certain amides that inhibit the growth of eukaryotic cells as probes in binding assays, said amides having the structural formula wherein A is cycloalkyl, alkyl, haloalkyl, alkylthio, haloalkylthio, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkoxy, haloalkoxy, or phenyl, pyridyl, furyl, thienyl, isoxazolyl, oxazolyl, pyrrolyl, isothiazolyl, thiazolyl, pyrazolyl, imidazolyl, pyrimidinyl, quinolyl, isoquinolyl, naphthyl, pyridazinyl, pyrazinyl, benzothienyl, indolyl, benzofuranyl or benzyl, all optionally substituted in an acceptable manner with up to 4 substituents; R1 and R2 are each independently a hydrogen atom, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, provided that both R1 and R2 are not a hydrogen atom; and X, Y and Z are each independently a hydrogen atom, halo, cyano, thiocyano, isothiocyano or alkylsulfonyloxy, provided that at least one of X, Y and Z is not a hydrogen atom; or the optical enantiomers thereof.

  本发明涉及筛选具有抗微管蛋白活性的化合物的方法，评估细胞对抗微管蛋白药物的敏感性，监测耐药性并使用抑制真核细胞生长的某些酰胺作为探针在结合测定中量化微管蛋白，其中所述酰胺具有结构式，其中A是环烷基，烷基，卤代烷基，烷基硫醚，卤代烷基硫醚，烯基，卤代烯基，炔基，卤代炔基，烷氧基，卤代烷氧基或苯基，吡啶基，呋喃基，噻吩基，异噁唑基，噁唑基，吡咯基，异噻唑基，噻唑基，吡唑基，咪唑基，吲哚基，苯并呋喃基或苄基，所有这些基团都可以以可接受的方式取代最多4个取代基; R1和R2各自独立地是氢原子，烷基，卤代烷基，烯基，卤代烯基，炔基或卤代炔基，前提是R1和R2都不是氢原子; X，Y和Z各自独立地是氢原子，卤素，氰基，硫氰基，异硫氰基或烷基磺酰氧基，前提是X，Y和Z中至少有一个不是氢原子; 或其光学对映体。
• Method for inhibiting the growth of mammalian cells
  申请人：Rohm and Haas Company

  公开号：US06140362A1

  公开（公告）日：2000-10-31

  A method for inhibiting mammalian cell growth is disclosed. The method uses compounds known as N-acetonylarylamides. The compounds have been shown to inhibit cell mitosis and to inhibit microtubule assembly. The method may be used to treat diseases associated with rapid cell growth, particularly cancer. The compounds used in the method of the present invention may be used in combination with other therapies and may be administered by known techniques for drug administration.

  本发明公开了一种抑制哺乳动物细胞生长的方法。该方法使用被称为N-乙酰基苯胺的化合物。已经证明这些化合物可以抑制细胞有丝分裂并抑制微管组装。该方法可用于治疗与快速细胞生长有关的疾病，特别是癌症。本发明方法中使用的化合物可以与其他治疗方法结合使用，并且可以通过已知的药物管理技术进行给药。