propane-1,3-diyl bis(3-(4-hydroxy-3,5-diiodophenyl)propanoate) | 1221279-42-0

• 分子结构分类: 有机化合物
• 英文名称: propane-1,3-diyl bis(3-(4-hydroxy-3,5-diiodophenyl)propanoate)
• 英文别名: 3-[3-(4-Hydroxy-3,5-diiodophenyl)propanoyloxy]propyl 3-(4-hydroxy-3,5-diiodophenyl)propanoate
• CAS: 1221279-42-0
• 化学式: C₂₁H₂₀I₄O₆
• 分子量: 876.004
• InChiKey: ADIHBFZROIJMIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,5-二碘-4-羟基苯丙酸 、 1,3-丙二醇 在 对甲苯磺酸 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 propane-1,3-diyl bis(3-(4-hydroxy-3,5-diiodophenyl)propanoate)
  参考文献：
  名称：

  POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES

  摘要：

  本发明提供了新型酚类化合物，包括从酪醇和类似物中衍生的化合物，用作生物相容性聚合物的单体，以及从这些单体酚化合物制备的生物相容性聚合物，包括新型可降解和/或可吸收的聚合物。这些生物相容性聚合物或具有增强生物吸收性和加工性能的聚合物组合物在各种医疗应用中非常有用，例如在医疗器械和控释治疗配方中。该发明还提供了制备这些单体酚化合物和生物相容性聚合物的方法。

  公开号：

  US20130203713A1

文献信息

• Polymeric biomaterials derived from monomers comprising hydroxyacids and phenol compounds and their medical uses
  申请人：Rutgers, The State University of New Jersey

  公开号：US10329379B2

  公开（公告）日：2019-06-25

  The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogs, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.

  本发明提供了源自羟基酸和酪醇或酪醇类似物的新型酚类化合物，可用作制备生物相容性聚合物的单体，以及由这些羟基酸-酚类化合物单体制备的生物相容性聚合物，包括新型生物可降解和/或生物可吸收聚合物。这些生物相容性聚合物或聚合物组合物具有更强的生物可吸收性和可加工性，可用于各种医疗应用，如医疗器械和控释治疗制剂。本发明还提供了制备这些单体羟基酸酚类化合物和生物相容性聚合物的方法。
• POLYMERIC BIOMATERIALS DERIVED FROM MONOMERS COMPRISING HYDROXYACIDS AND PHENOL COMPOUNDS AND THEIR MEDICAL USES
  申请人：Rutgers, The State University of New Jersey

  公开号：US20190292312A1

  公开（公告）日：2019-09-26

  The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processability are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric hydroxyacid-phenolic compounds and biocompatible polymers.
• MULTI-BLOCK COPOLYMER COMPOSITIONS
  申请人：REVA Medical, Inc.

  公开号：US20210040314A1

  公开（公告）日：2021-02-11

  Methods of making multi-block copolymer that reduce the tendency for large phase domains to form provide copolymer compositions that are useful for various applications, including the manufacture of medical devices.