青霉素 O 钾 | 897-61-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 青霉素 O 钾
• 中文别名: 青霉素 O 钾；青霉素O钾
• 英文名称: 6β-(2-allylsulfanyl-acetylamino)-penicillanic acid; potassium salt
• 英文别名: 6β-(2-allylmercapto-acetylamino)-penicillanic acid ; potassium-salt；6β-(2-Allylmercapto-acetylamino)-penicillansaeure; Kalium-Salz；potassium penicillin；potassium;N-[(2S,5R,6R)-2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl]-2-prop-2-enylsulfanylethanimidate
• CAS: 897-61-0
• 化学式: C₁₃H₁₇N₂O₄S₂*K
• 分子量: 368.519
• InChiKey: ONYTXCTVWDZLFD-GITWGATASA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.79
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  140
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  allylester 、 tetrakis (triphenylphosphone)palladium 、 乙醚 、 potassium 2-ethylhexanoate 生成 青霉素 O 钾
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
  申请人：Rogers D. Robin

  公开号：US20070093462A1

  公开（公告）日：2007-04-26

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  揭示了离子液体及制备活性药物、生物、营养和能量成分的离子液体组合物的方法。还揭示了利用本文描述的组合物的方法，以克服多型性、克服溶解度和输送问题、控制释放速率、增加功能性、增强功效（协同作用）以及改善易用性和制造工艺。
• [EN] A METHOD FOR PREPARING PENICILLIN G PROCAINE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LA PROCAINE PENICILLINNE G
  申请人：CROSS VETPHARM GROUP LTD

  公开号：WO2006016347A1

  公开（公告）日：2006-02-16

  A process for preparing penicillin G procaine comprises the steps of introducing inactive ingredients into a first mixing tank and sterilising the mixture of inactive ingredients in the first mixing tank. A procaine hydrochloride is dissolved in a second mixing tank, and the contents of the second mixing tank are added to the first mixing tank through a sterile filter. A solution of penicillin G potassium is introduced to the first mixing tank through a sterile filter, and the contents of the first mixing tank are mixed so that the procaine hydrochloride reacts with the penicillin G potassium forming penicillin G procaine. The resulting suspension is transferred through a homogeniser to a holding tank and penicillin G procaine is filled into a container.

  制备盐酸青霉素G丙酸盐的过程包括以下步骤：将无活性成分引入第一个混合罐中，并在第一个混合罐中对无活性成分的混合物进行灭菌处理。将盐酸丙胺溶解在第二个混合罐中，然后通过无菌过滤器将第二个混合罐中的内容加入到第一个混合罐中。将青霉素G钾的溶液通过无菌过滤器引入第一个混合罐中，然后混合第一个混合罐中的内容，使盐酸丙胺与青霉素G钾反应生成盐酸青霉素G丙酸盐。将得到的悬浮液通过均质器转移到保持罐中，然后将盐酸青霉素G丙酸盐灌装到容器中。
• COMPOUND HAVING DETRUSOR MUSCLE-CONTRACTING ACTIVITY AND URETHRAL SPHINCTER MUSCLE-RELAXING ACTIVITY
  申请人：Ohmoto Kazuyuki

  公开号：US20120088805A1

  公开（公告）日：2012-04-12

  Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a prodrug thereof, a mixture with a diastereomer thereof in an arbitrary ratio, or a cyclodextrin clathrate thereof have a contracting activity of bladder detrusor and a relaxing activity of urethral sphincter, they can ameliorate bladder contraction dysfunction and/or urethral relaxation dysfunction, and for example, are effective for underactive bladder. Additionally, the compound of the present invention has little risk of side effects on the urinary system, the circulatory system and the digestive system, and exhibits excellent pharmacokinetics, such as oral absorbability etc. Therefore, the compound of the present invention is useful as a superior agent for preventing, treating and/or ameliorating underactive bladder.

  由式(I)所代表的化合物，其中所有符号的定义与说明书中相同，其盐、溶剂合物、前药、任意比例的对映异构体混合物或环糊精包合物具有收缩膀胱去甲肌活性和放松尿道括约肌活性，它们可以改善膀胱收缩功能障碍和/或尿道松弛功能障碍，例如，对于无力膀胱非常有效。此外，本发明的化合物对泌尿系统、循环系统和消化系统的副作用风险很小，并表现出优异的药代动力学，如口服吸收等。因此，本发明的化合物在预防、治疗和/或改善无力膀胱方面具有优越的作用。
• Curcumin Conjugates and Methods of Use Thereof
  申请人：Augusta University Research Institute, Inc.

  公开号：US20180110861A1

  公开（公告）日：2018-04-26

  Curcumin-based conjugates and methods of use thereof are provided. Pharmaceutical compositions including an effective amount of one or more curcumin conjugates are also provided. In particular embodiments, the compositions are formulated for oral delivery. The conjugates and pharmaceutical compositions thereof can be administered to a subject in need thereof to treat a host of diseases and disorders including but not limited to, cancer, inflammation, and microbial growth.

  提供基于姜黄素的共轭物及其使用方法。还提供包括一种或多种姜黄素共轭物的有效量的制药组合物。在特定实施例中，这些组合物是为口服递送而制剂的。这些共轭物和其制药组合物可以被用于治疗患有多种疾病和障碍的患者，包括但不限于癌症、炎症和微生物生长。
• Multi-Functional Ionic Liquid Compositions for Overcoming Polymorphism and Imparting Improved Properties for Active Pharmaceutical, Biological, Nutritional, and Energetic Ingredients
  申请人：Rogers Robin D.

  公开号：US20120264605A1

  公开（公告）日：2012-10-18

  Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.

  本发明涉及离子液体和制备含有活性制药、生物、营养和能量成分的离子液体组合物的方法。同时，本发明还涉及使用所述组合物的方法，以克服多晶性、克服溶解度和输送问题、控制释放速率、增加功能、增强功效（协同作用）和改善使用和制造的便利性。