4,4-二氨基-3,3-二氟联苯 | 448-97-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,4-二氨基-3,3-二氟联苯
• 英文名称: 3,3'-difluorobiphenyl-4,4'-diamine
• 英文别名: 3,3'-difluorobenzidine；3,3'-difluoro-benzidine；3,3'-Difluor-benzidin；4-(4-amino-3-fluorophenyl)-2-fluoroaniline
• CAS: 448-97-5
• 化学式: C₁₂H₁₀F₂N₂
• 分子量: 220.222
• InChiKey: LVNPGQZSPDFZNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2921590090
• 危险性防范说明：
  P260,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4,4’-Diamino-3,3’-difluorobiphenyl
Synonyms: 3,3’-Difluorobiphenyl-4,4’-diamine

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4,4’-Diamino-3,3’-difluorobiphenyl
CAS number: 448-97-5

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H10F2N2
Molecular weight: 220.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4,4-二氨基-3,3-二氟联苯 在 吡啶 、 potassium carbonate 、 巯基乙酸 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三氟乙酸 、 potassium iodide 、 lithium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 110.0h， 生成
  参考文献：
  名称：

  通过双稳态[2]轮烷中的光触发关闭实现双吸收光谱变化，且无损读数

  摘要：

  双稳态[2]轮烷中偶氮苯（AB）单元的光触发光异构化会导致大环在哑铃上穿梭，从而产生独特的双重光谱变化特征：1）光谱...

  DOI：

  10.1039/c6cc08314e
• 作为产物：
  描述：

  2,2'-difluoroazobenzene 在 盐酸 、 sodium amalgam 、 乙醇 作用下， 生成 4,4-二氨基-3,3-二氟联苯
  参考文献：
  名称：

  Olah et al., Acta Chimica Academiae Scientiarum Hungaricae, 1955, vol. 7, p. 71,82

  摘要：

  DOI：

文献信息

• Design, synthesis and biological evaluation of small-azo-dyes as potent Vesicular Glutamate Transporters inhibitors
  作者：Franck-Cyril Favre-Besse、Odile Poirel、Tiphaine Bersot、Elodie Kim-Grellier、Stephanie Daumas、Salah El Mestikawy、Francine C. Acher、Nicolas Pietrancosta

  DOI：10.1016/j.ejmech.2014.03.056

  日期：2014.5

  and dicarboxylic quinolines (DCQs). Their ability to block vesicular glutamate uptake was evaluated. Several compounds displayed low micromolar inhibitory potency when size related compounds are thirty to forty times less potent (i.e. DCQ). We then confirmed the VGLUT selectivity by measuring the effect of the series on vesicular monoamine transport and on metabotropic glutamate receptor activity.

  囊泡谷氨酸转运蛋白（VGLUT）允许装载突突前谷氨酸囊泡，因此在谷氨酸能突触传递中起关键作用。事实证明，VGLUT参与了几种主要的神经病理学，并且与阿尔茨海默氏症和帕金森氏病的临床痴呆症直接相关。因此，VGLUT代表用于神经病理学治疗或诊断的关键生物学靶标或生物标志物。然而，尽管VGLUT具有举足轻重的作用，但它们的药理作用似乎十分有限。已知的竞争性抑制剂仅限于某些染料，如锥虫蓝（TB）和谷氨酸盐模拟物。缺乏药理学工具严重阻碍了VGLUT的研究。在这里，我们报告了一种结合了结核病和二羧酸喹啉（DCQs）优点的小分子的快速获得方法。评价了它们阻断水泡谷氨酸摄取的能力。当与尺寸相关的化合物的效价低三十至四十倍时（即DCQ），几种化合物的微摩尔抑制力低。然后，我们通过测量该系列对囊泡单胺转运和代谢型谷氨酸受体活性的影响，证实了VGLUT的选择性。这些抑制剂仅需两个步骤即可合成，并且属于VGLUT研究的最佳药理工具。
• ACETYLENE COMPOUND, SALT THEREOF, CONDENSATE THEREOF, AND COMPOSITION THEREOF
  申请人：Fujifilm Corporation

  公开号：EP2202220A1

  公开（公告）日：2010-06-30

  [Problem to be Solved] To provide an acetylene compound having a structure in which a unit having an amino group and a unit having an ethynyl group are bonded via a linking group, the acetylene compound being introducable to a polymer having thermal resistance. [Means for Solving the Problem] An acetylene compound represented by the following Formula (1) and a salt thereof: wherein in Formula (1), X represents a single bond or a divalent linking group; A represents a hydrocarbon group, a heteroaromatic ring or a heteroalicyclic compound; B represents a hydrocarbon group, a heteroaromatic ring, a heteroalicyclic compound or a single bond; R1 represents a hydrogen atom, a hydrocarbon group, a heteroaromatic ring, a heteroalicyclic compound or a silyl group; R4 represents a hydrogen atom or a group that can be a substituent of an amino group; and m, n and a each independently represent an integer of 1 or greater.

  解决的问题是提供一种乙炔化合物，其结构中含有通过连接基团连接的具有氨基团和乙炔基团的单元，该乙炔化合物可引入到具有热阻抗的聚合物中。解决问题的方法是通过以下式（1）表示的乙炔化合物及其盐：其中在式（1）中，X代表单键或二价连接基团；A代表烃基团、杂环芳香环或杂环脂环化合物；B代表烃基团、杂环芳香环、杂环脂环化合物或单键；R1代表氢原子、烃基团、杂环芳香环、杂环脂环化合物或硅基团；R4代表氢原子或可作为氨基团的取代基团；m、n和a分别独立表示大于或等于1的整数。
• PROCESS AND APPARATUS FOR PRODUCTION OF COLORLESS TRANSPARENT RESIN FILM
  申请人：OISHI Jitsuo

  公开号：US20100187719A1

  公开（公告）日：2010-07-29

  A method for producing a colorless transparent resin film by a solution flow casting method containing: flow-casting an organic solvent solution of a polyamic acid or a polyimide on a support; and drying, the method containing at least the following step (1), step (2) and step (3) in this order, and an apparatus therefor: (1) a step of flow-casting an organic solvent solution of a polyamic acid or polyamide on a support, (2) a step of evaporating the organic solvent while blowing a gas having an oxygen content of from 0.001 to 15% by volume at a temperature of from 100 to 170° C. onto the flow-cast material, and releasing as a self-supporting film from the support, and (3) a step of performing the following step (3-1) and step (3-2) in this order: (3-1) a step of lowering a residual ratio of the organic solvent in the self-supporting film while blowing a gas having an oxygen content of 15% by volume or less at a temperature of from 100 to 250° C. onto the film by using at least one dryer of a type of blowing a heated gas, and (3-2) a step of lowering the residual ratio of the organic solvent in the self-supporting film while blowing a gas having an oxygen content of 5% by volume or less at a temperature of from 150 to 400° C. onto the film by using at least one dryer of a type of blowing a heated gas.

  一种通过溶液流铸法制备无色透明树脂薄膜的方法，包括：在支撑物上流铸聚酰胺酸或聚酰亚胺的有机溶剂溶液；并干燥，该方法至少包括以下步骤（1）、步骤（2）和步骤（3），并提供相应的设备：(1)在支撑物上流铸聚酰胺酸或聚酰亚胺的有机溶剂溶液；(2)在向流铸材料吹送氧含量为0.001至15%体积的气体的同时，蒸发有机溶剂，温度在100至170°C之间，从支撑物上释放为自支撑膜；(3)按照以下步骤（3-1）和步骤（3-2）的顺序执行：(3-1)在使用至少一种吹送加热气体的干燥器的情况下，以15%体积以下的氧含量的气体在100至250°C的温度下吹送，降低自支撑膜中有机溶剂的残留比率；(3-2)在使用至少一种吹送加热气体的干燥器的情况下，以5%体积以下的氧含量的气体在150至400°C的温度下吹送，降低自支撑膜中有机溶剂的残留比率。
• Low thermal expansion resin material for a wiring insulating film.
  申请人：HITACHI, LTD.

  公开号：EP0133533A2

  公开（公告）日：1985-02-27

  A resin material comprising a polyimide having as chemical structural unit at least one aromatic ring which can rotate around its molecular axis but has no flexibility at another direction, said polyimide being oriented at least at a uniaxial direction, has a low thermal expansion coefficient and can be shaped together with an inorganic material into one body to give a composite shaped article.

  一种由聚酰亚胺组成的树脂材料，其化学结构单元为至少一个芳香环，该芳香环可绕其分子轴旋转，但在另一个方向上没有柔韧性，所述聚酰亚胺至少在单轴方向上定向，具有较低的热膨胀系数，并可与无机材料塑合成一体，形成复合形状的物品。
• Wholly aromatic polyamide copolymer
  申请人：TEIJIN LIMITED

  公开号：EP0367535A1

  公开（公告）日：1990-05-09

  A wholly aromatic polyamide copolymer having excellent heat, flame and chemical resistances, solubility in organic solvents and shaping property and useful for shaped article having a high mechanical strength and modulus of elasticity, comprising the repeating units of the formulae: and at least one member selected from wherein X = a halogen atom, n, or m = 1 to 4 and n + m = 1 to 8.

  一种全芳香族聚酰胺共聚物，具有优异的耐热性、阻燃性和耐化学性，在有机溶剂中的溶解性和成型性能，可用于具有高机械强度和弹性模量的成型制品，由以下式子的重复单元组成： 和至少一个选自以下的成员 其中 X = 卤素原子，n 或 m = 1 至 4，n + m = 1 至 8。