4-hydroxybutyl triphosphate | 868157-98-6

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 4-hydroxybutyl triphosphate
• CAS: 868157-98-6
• 化学式: C₄H₁₃O₁₁P₃
• 分子量: 330.062
• InChiKey: ZGGXJDQJNUARAY-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  4-benzoyloxybutyl triphosphate 在 ammonium hydroxide 作用下， 反应 18.0h， 以45%的产率得到4-hydroxybutyl triphosphate
  参考文献：
  名称：

  Synthesis of Novel Alkyl Triphosphates and Their Substrate Properties Toward Terminal Deoxynucleotidyltransferase

  摘要：

  Novel triphosphate derivatives bearing bulky or small groups at alpha-position attached to the triphosphate residue through linkers of different structures and lengths were synthesized and studied as substrates toward terminal deoxynucleotidyltransferase. The substrate efficacy depends on the structure of substituents, linker length, and nature of metal activator. The replacement of hydrophobic groups by small substituents decreased the substrate efficacy by about 20 times in respect to hydrophobic residues. The dependence on metal activator is the following: Co2+ > Mn2+ >> Mg2+. The model of interaction of alkyl triphosphates with linkers of different lengths bearing TdT active site is presented.

  DOI：

  10.1080/15257770701296713