2-dimethylaminomethyl-1-methanesulfonyl-1H-indole-6-carboxylic acid hydrazide | 851211-64-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-dimethylaminomethyl-1-methanesulfonyl-1H-indole-6-carboxylic acid hydrazide
• 英文别名: 2-[(dimethylamino)methyl]-1-methylsulfonylindole-6-carbohydrazide
• CAS: 851211-64-8
• 化学式: C₁₃H₁₈N₄O₃S
• 分子量: 310.377
• InChiKey: NNPOSTJKZWRXHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[（2-本氧基乙基）硫代]乙酸 、 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 、 2-dimethylaminomethyl-1-methanesulfonyl-1H-indole-6-carboxylic acid hydrazide 、 2-dimethylaminomethyl-benzofuran-6-carboxylic acid N'-[2-(2-phenoxy-ethylsulfanyl)-acetyl]-hydrazide 以to obtain 2-dimethylaminomethyl-1-methanesulfonyl-1H-indole-6-carboxylic acid N′-[2-(2-phenoxy-ethylsulfanyl)-acetyl]-hydrazide (3.20 g, 93% yield) as a yellow foam的产率得到2-dimethylaminomethyl-1-methanesulfonyl-1H-indole-6-carboxylic acid N'-[2-(2-phenoxy-ethylsulfanyl)-acetyl]-hydrazide
  参考文献：
  名称：

  Novel mch receptor antagonists

  摘要：

  本发明涉及一种公式I的黑色素浓集激素拮抗剂化合物或其药学上可接受的盐，用于治疗H型糖尿病和/或肥胖症。

  公开号：

  US20070135485A1

文献信息

• NOVEL MCH RECEPTOR ANTAGONISTS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1723126A2

  公开（公告）日：2006-11-22
• COMPOUND FOR OPTICAL MATERIALS AND METHODS OF FABRICATION
  申请人：General Electric Company

  公开号：EP1732937A1

  公开（公告）日：2006-12-20
• [EN] NOVEL MCH RECEPTOR ANTAGONISTS<br/>[FR] NOUVEAUX ANTAGONISTES DES RECEPTEURS DE L'HORMONE MCH
  申请人：LILLY CO ELI

  公开号：WO2005040157A2

  公开（公告）日：2005-05-06

  The present invention relates to a melanin concentrating hormone antagonist compound of formula I: or a pharmaceutically acceptable salt thereof, useful for the treamtment useful fog treating Type H diabetes and/or obesity.
• [EN] COMPOUND FOR OPTICAL MATERIALS AND METHODS OF FABRICATION<br/>[FR] COMPOSE DESTINE A DES MATERIAUX OPTIQUES ET PROCEDES DE FABRICATION
  申请人：GEN ELECTRIC

  公开号：WO2005097843A1

  公开（公告）日：2005-10-20

  A polycyclic or monocyclic perfluorovinyl compound comprising at least one structural unit selected from the group consisting of formula I and formula II wherein M is independently at each occurrence a metal selected from group 14 of the periodic table of the elements; and R is independently at each occurrence a bond, a hydrogen, an aliphatic group, a cycloaliphatic group, or an aromatic group. The polycyclic or monocyclic compound comprises at least two perfluorovinyl groups. A method for making an optical film of the disclosed compound, an electro­optical device comprising a polymer fabricated from the disclosed compound and a polymer fabricated from the disclosed compound are also provided.