N-(1-Acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-(1-oxo-2,3-dihydro-1H-isoindol-4-ylamino)-nicotinamide | 618445-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(1-Acetyl-3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-(1-oxo-2,3-dihydro-1H-isoindol-4-ylamino)-nicotinamide
• 英文别名: N-(1-acetyl-3,3-dimethyl-2H-indol-6-yl)-2-[(1-oxo-2,3-dihydroisoindol-4-yl)amino]pyridine-3-carboxamide
• CAS: 618445-59-3
• 化学式: C₂₆H₂₅N₅O₃
• 分子量: 455.516
• InChiKey: VVPRDVBQCZPIOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Substituted amine derivatives and methods of use
  申请人：Amgen Inc.

  公开号：US20030203922A1

  公开（公告）日：2003-10-30

  Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的胺类化合物对于预防和治疗疾病，如血管生成介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药用可接受盐，用于预防和治疗涉及癌症等疾病和其他疾患或病况的药物组合物和方法。该发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
• SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATED DISORDERS
  申请人：AMGEN INC.

  公开号：EP1562933B1

  公开（公告）日：2008-03-19
• US7102009B2
  申请人：——

  公开号：US7102009B2

  公开（公告）日：2006-09-05
• [EN] SUBSTITUTED AMINE DERIVATIVES AND METHODS OF USE IN THE TREATMENT OF ANGIOGENESIS RELATES DISORDERS<br/>[FR] DERIVES D'AMINES SUBSTITUEES ET PROCEDES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2004007481A2

  公开（公告）日：2004-01-22

  Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.