Synthesis of New 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl Radicals and 2-Substituted-2,5,5-trimethylpyrrolidin-1-yloxyl Radicals Based α-Amino Acids
Synthesis of New 2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrol-1-yloxyl Radicals and 2-Substituted-2,5,5-trimethylpyrrolidin-1-yloxyl Radicals Based α-Amino Acids
Synthesis and resolution of new paramagnetic α-amino acids
作者:Tamás Kálai、József Schindler、Mária Balog、Elemér Fogassy、Kálmán Hideg
DOI:10.1016/j.tet.2007.11.020
日期:2008.2
New, paramagnetic unnatural α-aminoacids were synthesized by the O'Donnell method. In the new aminoacids nitroxide is condensed with thiophene, benzene, and tetrahydroisoquinoline ring, or linked through a methylene, benzyl or propargyl spacer. Some of the racemic paramagnetic α-aminoacid esters described earlier or in this work were resolved by fractional crystallization of diastereomeric salts