The natural amino acid L-cysteine, commercially available aldehydes, and 3-(acetylsulfanyl)propionyl chloride were used for the synthesis of 2-substituted (2R,4R)-3-(3-mercaptopropionyl)thiazolidine-4-carboxylic acids, potential antihypertensive drugs with angiotensin converting enzyme inhibiting action.
天然
氨基酸L-半胱氨酸,市售醛和3-(乙酰基
硫烷基)
丙酰氯用于合成2-取代的(2R,4R)-3-(3-巯基丙酰)
噻唑烷-4-
羧酸降压药具有抑制
血管紧张素转化酶的作用。