8-cyclopentyl-2-((4-morpholinophenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | 1357470-30-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 8-cyclopentyl-2-((4-morpholinophenyl)amino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
• 英文别名: Pyrido[2,3-d]pyrimidine-6-carbonitrile, 8-cyclopentyl-7,8-dihydro-2-[[4-(4-morpholinyl)phenyl]amino]-7-oxo-；8-cyclopentyl-2-(4-morpholin-4-ylanilino)-7-oxopyrido[2,3-d]pyrimidine-6-carbonitrile
• CAS: 1357470-30-4
• 化学式: C₂₃H₂₄N₆O₂
• 分子量: 416.483
• InChiKey: XGTHJEPWJGOISN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  94.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF<br/>[FR] 8-ALKYL-7-OXO-7, 8DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES SUBSTITUÉS EN 2 ET LEURS UTILISATIONS
  申请人：UNIV TEMPLE

  公开号：WO2012018540A1

  公开（公告）日：2012-02-09

  Compounds according to Formula (I), as well as salts thereof: wherein R1 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of Formula (I) are also provided.

  根据式（I）的化合物及其盐：其中R1和R2如本文所定义，可用作抗增殖剂和激酶抑制剂。还提供了制备式（I）化合物的合成方法。
• 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF
  申请人：Reddy E. Premkumar

  公开号：US20130131058A1

  公开（公告）日：2013-05-23

  Compounds according to Formula (I), as well salts thereof: wherein R 1 and R 2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of Formula (I) are also provided.

  根据化学式（I）及其盐，其中R1和R2的定义如下，这些化合物可用作抗增殖剂和激酶抑制剂。本发明还提供了制备化学式（I）化合物的合成方法。
• 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBONITRILES AND USES THEREOF
  申请人：Temple University - Of The Commonwealth System of Higher Education

  公开号：EP2600719B1

  公开（公告）日：2014-10-08
• EP3125920B1
  申请人：——

  公开号：EP3125920B1

  公开（公告）日：2020-12-23
• USE OF DIANHYDROGALACTITOL AND ANALOGS OR DERIVATIVES THEREOF IN COMBINATION WITH PLATINUM-CONTAINING ANTINEOPLASTIC AGENTS TO TREAT NON-SMALL-CELL CARCINOMA OF THE LUNG AND BRAIN METASTASES
  申请人：Del Mar Pharmaceuticals

  公开号：US20160008316A1

  公开（公告）日：2016-01-14

  The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of non-small-cell lung carcinoma (NSCLC) and ovarian cancer, as well as other types of malignancy, including brain metastases of NSCLC. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N 7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide, cisplatin, and tyrosine kinase inhibitors; the drug acts independently of the MGMT repair mechanism. Dianhydrogalactitol can be used together with other anti-neoplastic agents and can possess additive or super-additive effects.