2-[5-(tert-butyl(dimethyl)silanyloxy)-2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-pentyl]-malonic acid dimethyl ester | 1159486-42-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[5-(tert-butyl(dimethyl)silanyloxy)-2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-pentyl]-malonic acid dimethyl ester
• CAS: 1159486-42-6
• 化学式: C₃₂H₆₂N₂O₇Si
• 分子量: 614.939
• InChiKey: ZAHKBOCTENWCCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  42.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  94.61
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-malonic acid dimethyl ester 、 tert-butylpent-4-enyloxydimethylsilane 以 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以92%的产率得到2-[5-(tert-butyl(dimethyl)silanyloxy)-2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-pentyl]-malonic acid dimethyl ester
  参考文献：
  名称：

  Microflow Radical Carboaminoxylations with a Novel Alkoxyamine

  摘要：

  Highly efficient thermal radical carboaminoxylations of various olefins by using the novel alkoxyamine A to give adducts of type B are described. It is reported that these radical addition reactions can be performed in a microflow reaction system. As compared to conventional batch reaction setup, significantly higher yields are obtained by running carboaminoxylations using the microflow system under analogous conditions.

  DOI：

  10.1021/ol900713d