1-[3-(3-hydroxyphenyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione | 1202800-10-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[3-(3-hydroxyphenyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl]-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione
• 英文别名: 1-[3-(3-hydroxyphenyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]-2-[4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione
• CAS: 1202800-10-9
• 化学式: C₂₅H₂₂N₈O₄
• 分子量: 498.501
• InChiKey: DZYFGAYJDJAZAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  144
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS<br/>[FR] DICÉTO-AZOLOPIPÉRIDINES ET AZOLOPIPÉRAZINES EN TANT QU'AGENTS ANTI-VIH
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2009158394A1

  公开（公告）日：2009-12-30

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives that possess unique antiviral activity are provided. These compounds are useful the treatment of HIV and AIDS.

  具有药物和生物影响特性的化合物，其药物组合物和使用方法已经列出。具体来说，提供了具有独特抗病毒活性的二酮融合的咪唑哌啶和咪唑哌嗪衍生物。这些化合物对治疗艾滋病毒和艾滋病非常有用。
• DIKETO AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2303876B1

  公开（公告）日：2014-03-19
• Diketo Fused Azolopiperidines and Azolopiperazines as Anti-HIV Agents
  申请人：Wang Tao

  公开号：US20100009993A1

  公开（公告）日：2010-01-14

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives that possess unique antiviral activity are provided. These compounds are useful for the treatment of HIV and AIDS.
• DIKETO FUSED AZOLOPIPERIDINES AND AZOLOPIPERAZINES AS ANTI-HIV AGENTS
  申请人：Wang Tao

  公开号：US20110212971A1

  公开（公告）日：2011-09-01

  Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, diketo fused azolopiperidine and azolopiperazine derivatives that possess unique antiviral activity are provided. These compounds are useful for the treatment of HIV and AIDS.
• US7960406B2
  申请人：——

  公开号：US7960406B2

  公开（公告）日：2011-06-14