4-Prop-2-enylpyrrolidin-3-amine | 124574-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-Prop-2-enylpyrrolidin-3-amine
• CAS: 124574-13-6
• 化学式: C₇H₁₄N₂
• mdl: MFCD19211035
• 分子量: 126.202
• InChiKey: XWQOMFNQWYFXRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-Prop-2-enylpyrrolidin-3-amine 、 苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Kawada, Kenji; Tsushima, Tadahiko, Heterocycles, 1989, vol. 28, # 2, p. 573 - 578

  摘要：

  DOI：
• 作为产物：
  描述：

  (+/-)-trans-4-allyl-3-hydroxypyrrolidine 在 盐酸肼 、 三丁基膦 、 sodium cyanoborohydride 、 二苯二硫醚 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 吡啶 、 乙醇 、 二氯甲烷 为溶剂， 生成 4-Prop-2-enylpyrrolidin-3-amine
  参考文献：
  名称：

  Kawada, Kenji; Tsushima, Tadahiko, Heterocycles, 1989, vol. 28, # 2, p. 573 - 578

  摘要：

  DOI：

文献信息

• [EN] NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER<br/>[FR] NOUVEAUX 4-AMINO-N-HYDROXY-BENZAMIDES EN TANT QU'INHIBITEURS DE HDAC POUR LE TRAITEMENT DU CANCER
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012098132A1

  公开（公告）日：2012-07-26

  The present invention provides hdac inhibitors of formula (I), or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.

  本发明提供了式(I)的HDAC抑制剂，或其药学上可接受的盐、酯或立体异构体，其中R1至R4、A和Y具有本文中给出的含义，以及制备这些化合物的方法以及它们作为药物的用途，特别是作为治疗癌症的药物。
• NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER
  申请人：Lin Xianfeng

  公开号：US20120190700A1

  公开（公告）日：2012-07-26

  The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R 1 to R 4 , A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.

  本发明提供了以下结构的化合物或其药用盐、酯或立体异构体，其中R1至R4、A和Y具有本文中给出的含义，以及制备这些化合物的方法以及它们作为药物的用途，特别是作为治疗癌症的药物。
• AMINOARYL OXAZOLIDINONE N-OXIDES
  申请人：——

  公开号：US20020177707A1

  公开（公告）日：2002-11-28

  The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula I 1 wherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of these compounds. They are also rapidly converted back to the parent amines in vivo, making them useful as prodrugs of the parent amines. They are effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp., and in organisms such as Mycoplasma spp.

  本发明提供了公式I1中的氨基芳基噁唑啉酮N-氧化物化合物，其中变量如定义所述。这些化合物在水中极易溶解，这对于制备这些化合物的药物配方非常有用。它们也能够在体内迅速转化为原始胺类化合物，这使它们成为原始胺类化合物的前药。它们对许多人类和兽医病原体具有有效作用，包括革兰氏阳性的需氧菌，如耐多种抗生素的葡萄球菌、链球菌和肠球菌，以及厌氧菌，如拟杆菌属和梭菌属物种，和酸性快速生长菌，如结核分枝杆菌、埃及分枝杆菌和分枝杆菌属，以及支原体属等微生物。
• Aminoaryl Oxazolidinone N-oxides
  申请人：——

  公开号：US20010051722A1

  公开（公告）日：2001-12-13

  The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula I 1 wherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of these compounds. They are also rapidly converted back to the parent amines in vivo, making them useful as prodrugs of the parent amines. They are effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp., and in organisms such as Mycoplasma spp.

  本发明提供了一种式为I1的氨基芳基噁唑啉酮N-氧化物化合物，其中变量的定义如本文所述。这些化合物在水中极易溶解，这对于制备这些化合物的药物配方非常有用。它们在体内也能迅速转化回母体胺，因此可作为母体胺的前药物使用。它们对许多人类和兽医病原体具有有效作用，包括革兰氏阳性的需氧菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌，如Bacteroides spp.和Clostridia spp.菌种，以及抗酸菌，如结核分枝杆菌、埃及分枝杆菌和分枝杆菌属，以及支原体属等生物。
• Aminoaryl oxazolidinone N-oxides
  申请人：——

  公开号：US20020107402A1

  公开（公告）日：2002-08-08

  The present invention provides for aminoaryl oxazolidinone N-oxide compounds of Formula I 1 wherein the variables are as defined herein. These compounds are exceedingly water soluble which is useful in preparing pharmaceutical formulations of these compounds. They are also rapidly converted back to the parent amines in vivo, making them useful as prodrugs of the parent amines. They are effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms, such as Bacteroides spp. and Clostridia spp. species, and acid-fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp., and in organisms such as Mycoplasma spp.

  本发明提供了一种公式I1的氨基芳基噁唑烷N-氧化物化合物，其中变量如此处所定义。这些化合物在水中极易溶解，可用于制备这些化合物的制药配方。它们在体内也能迅速转化为母体胺类化合物，因此可用作母体胺类化合物的前药。它们对许多人类和兽医病原体具有有效作用，包括革兰氏阳性的需氧菌，如多重耐药葡萄球菌、链球菌和肠球菌，以及厌氧菌，如Bacteroides spp.和Clostridia spp.物种，还有抗酸菌，如结核分枝杆菌、非结核分枝杆菌和分枝杆菌属，以及支原体属等。