[palladium(II)(1,10-phenanthroline)(ethyldithiocarbamate)]nitrate | 1243265-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: [palladium(II)(1,10-phenanthroline)(ethyldithiocarbamate)]nitrate
• 英文别名: [Pd(phen)(Et-dtc)]nitrate；ethyldithiocarbamato-1,10-phenanthroline palladium(II) nitrate
• CAS: 1243265-66-8
• 化学式: C₁₅H₁₄N₃PdS₂*NO₃
• 分子量: 468.853
• InChiKey: GLMLSQXDSQZEMX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [Pd(phen)Br₂] 、 乙基二硫代氨基甲酸单钠盐 以 not given 为溶剂， 以54%的产率得到[palladium(II)(1,10-phenanthroline)(ethyldithiocarbamate)]nitrate
  参考文献：
  名称：

  Interaction studies between a 1,10-phenanthroline adduct of palladium(II) dithiocarbamate anti-tumor complex and calf thymus DNA. A synthesis spectral and in-vitro study

  摘要：

  The interaction of calf thymus DNA (CT-DNA) with a novel synthesized and characterized Palladium (II) complex with the formula of [Pd (Et-dtc) (phen)] NO3 (where phen is 1,10-phenanthroline and Et-dtc is ethyldithiocarbamate) was extensively studied by various spectroscopic techniques. UV-vis studies imply that there is a set of 6 binding sites for the complex on DNA with positive cooperativity in the binding process. This complex unexpectedly denatures the DNA at very low concentration (similar to 9.8 mu M). Gel filtration studies indicate that the binding of metal complex with DNA is strong enough not to readily break. Fluorescence studies show that the palladium complex intercalates in DNA through the planar 1,10-phenanthroline ligand presented in its structure. Several binding and thermodynamic parameters are also described. Furthermore, anti-tumor studies of this water soluble complex against human cell tumor lines (K562) have been done. It shows 50% cytotoxic concentration (Ic(50)) value much lower than that of cisplatin. (c) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2010.05.029