| 1526934-80-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• CAS: 1526934-80-4
• 化学式: C₂₉H₃₃F₃O₄
• 分子量: 502.574
• InChiKey: OGOCDKMHFHFNEI-ZBVBGGFBSA-N

反应信息

• 作为产物：
  描述：

  3α-hydroxy-12-methoxy-13-methyl-ent-podocarp-6,8,11,13-tetraene 、 (R)-methoxytrifluoromethylphenylacetyl chloride 在 吡啶 作用下， 反应 3.0h， 生成
  参考文献：
  名称：

  Anti-Hepatitis C Virus Dinorditerpenes from the Roots of Flueggea virosa

  摘要：

  Along with four known terpenoids (1-4), eight new dinorditerpenes (5-12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4-6 were determined by the Mosher's method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC50,values of 5.6, 5.0, 7.5, and 6.6 mu M, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.

  DOI：

  10.1021/np400528h