(2R,4S)-2-aminomethyl-4-methyl-heptanoic acid | 610300-31-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R,4S)-2-aminomethyl-4-methyl-heptanoic acid
• 英文别名: (2R,4S)-2-(aminomethyl)-4-methylheptanoic acid
• CAS: 610300-31-7
• 化学式: C₉H₁₉NO₂
• 分子量: 173.255
• InChiKey: IVYDEZGCXPEAHO-JGVFFNPUSA-N

物化性质

• 沸点：
  282.9±23.0 °C(Predicted)
• 密度：
  0.983±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Methods for using amino acids with affinity for the alpha2delta-protein
  申请人：Bramson Candace

  公开号：US20050124669A1

  公开（公告）日：2005-06-09

  This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

  本发明涉及一些与钙通道的α2δ亚单位结合的β-氨基酸。这些化合物及其药学上可接受的盐在治疗各种精神疾病、疼痛和其他疾病方面是有用的。
• Amino acids with affinity for the alpha-2-delta-protein
  申请人：Barta Sue Nancy

  公开号：US20060154972A1

  公开（公告）日：2006-07-13

  This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.

  本发明涉及与钙通道的α2δ亚单位结合的某些β-氨基酸。这些化合物及其药学上可接受的盐在治疗各种精神疾病、疼痛和其他疾病中具有用处。
• Pharmaceutical composition for the prevention and treatment of addiction in a mammal
  申请人：Coe Wadsworth Jotham

  公开号：US20050043345A1

  公开（公告）日：2005-02-24

  Pharmaceutical compositions are disclosed for the treatment of alcohol or cocaine dependence or addiction, tobacco dependence or addiction, reduction of alcohol withdrawal symptoms or aiding in the cessation or lessening of alcohol use or substance abuse or other behavioral dependencies including gambling. The pharmaceutical compositions are comprised of a therapeutically effective combination of an opioid receptor antagonist and an alpha2delta ligand and a pharmaceutically acceptable carrier. The method of using these compounds is also disclosed.
• US7064147B2
  申请人：——

  公开号：US7064147B2

  公开（公告）日：2006-06-20
• US7112610B2
  申请人：——

  公开号：US7112610B2

  公开（公告）日：2006-09-26