2,3-Bis-pentacosa-10,12-diynoylamino-propionic acid | 314725-67-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,3-Bis-pentacosa-10,12-diynoylamino-propionic acid
• CAS: 314725-67-2
• 化学式: C₅₃H₈₈N₂O₄
• 分子量: 817.293
• InChiKey: IBZPLHPBUSSQLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.55
• 重原子数：
  59.0
• 可旋转键数：
  40.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  95.5
• 氢给体数：
  3.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2,3-Bis-pentacosa-10,12-diynoylamino-propionic acid 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 20.0h， 生成 Pentacosa-10,12-diynoic acid (1-{2-[2-(2-amino-ethoxy)-ethoxy]-ethylcarbamoyl}-2-pentacosa-10,12-diynoylamino-ethyl)-amide
  参考文献：
  名称：

  Synthesis of Metal-Chelating Lipids to Sensitize Lanthanide Ions

  摘要：

  Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.

  DOI：

  10.1021/jo026833k
• 作为产物：
  描述：

  2,3-Bis-pentacosa-10,12-diynoylamino-propionic acid methyl ester 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 24.0h， 以97%的产率得到2,3-Bis-pentacosa-10,12-diynoylamino-propionic acid
  参考文献：
  名称：

  Polymerized Fluorescent Liposomes Incorporating Lanthanide Ions

  摘要：

  [GRAPHICS]This paper describes the design and synthesis of a polymerizable lipid capable of complexing lanthanide ions. The lipid has been successfully incorporated into liposomes and then polymerized. Fluorescence studies indicate that the diacetylene (unpolymerized lipid) and the conjugated alkenes (after polymerization) can be used as sensitizers for the lanthanide ion.

  DOI：

  10.1021/ol006357p

文献信息

• Recognition of isozymes via lanthanide ion incorporated polymerized liposomes
  作者：Adekunle I. Elegbede、Manas K. Haldar、Sumathra Manokaran、Sanku Mallik、D. K. Srivastava

  DOI：10.1039/b709815d

  日期：——

  We report the selective recognition of carbonic anhydrase isozymes based on the excited-state lifetimes of chelated Eu3+ ions incorporated in polymerized liposomes.

  我们报告了根据聚合脂质体中螯合 Eu3+ 离子的激发态寿命对碳酸酐酶同工酶的选择性识别。