(R)-2,3-bis(tetradecyloxy)propyl (2,5-dioxopyrrolidin-1-yl) carbonate | 1019000-58-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (R)-2,3-bis(tetradecyloxy)propyl (2,5-dioxopyrrolidin-1-yl) carbonate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) [(2R)-2,3-di(tetradecoxy)propyl] carbonate
• CAS: 1019000-58-8
• 化学式: C₃₆H₆₇NO₇
• 分子量: 625.93
• InChiKey: WCVQOAXYYWEBNE-MGBGTMOVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.01
• 重原子数：
  44.0
• 可旋转键数：
  32.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  91.37
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  (R)-2,3-bis(tetradecyloxy)propyl (2,5-dioxopyrrolidin-1-yl) carbonate 、 2-(2-(2-氨基乙氧基)乙氧基)乙基氨基甲酸叔丁酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以86.2 %的产率得到(R)-2,3-bis(tetradecyloxy)propyl (2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-yl)carbamate
  参考文献：
  名称：

  [EN] THERMOSTABLE LIPID NANOPARTICLE AND METHODS OF USE THEREOF
  [FR] NANOPARTICULE LIPIDIQUE THERMOSTABLE ET SES MÉTHODES D'UTILISATION

  摘要：

  The present disclosure provides, among other things, a lipid nanoparticle adjuvant composition. The present disclosure provides pharmaceutical compositions that include a stable lipid nanoparticle adjuvant and human papillomavirus (HPV) virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.

  公开号：

  WO2023023152A1
• 作为产物：
  描述：

  溴代十四烷 在 palladium 10% on activated carbon 、 氢气 、 palladium(II) hydroxide 、 三乙胺 、 potassium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 155.0 ℃ 、344.75 kPa 条件下， 反应 29.0h， 生成 (R)-2,3-bis(tetradecyloxy)propyl (2,5-dioxopyrrolidin-1-yl) carbonate
  参考文献：
  名称：

  [EN] THERMOSTABLE LIPID NANOPARTICLE AND METHODS OF USE THEREOF
  [FR] NANOPARTICULE LIPIDIQUE THERMOSTABLE ET SES MÉTHODES D'UTILISATION

  摘要：

  The present disclosure provides, among other things, a lipid nanoparticle adjuvant composition. The present disclosure provides pharmaceutical compositions that include a stable lipid nanoparticle adjuvant and human papillomavirus (HPV) virus-like particles (VLPs) of at least one type of human papillomavirus (HPV) selected from the group consisting of HPV types: 6, 11, 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 55, 56, 58, 59, 66, 68, 73, and 82.

  公开号：

  WO2023023152A1

文献信息

• [EN] REVERSE HEAD GROUP LIPIDS, LIPID PARTICLE COMPOSITIONS COMPRISING REVERSE HEADGROUP LIPIDS, AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS<br/>[FR] LIPIDES À TÊTES POLAIRES INVERSÉES, COMPOSITIONS PARTICULAIRES LIPIDIQUES COMPRENANT LES LIPIDES À TÊTES POLAIRES INVERSÉES, ET PROCÉDÉS D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：UNIV BRITISH COLUMBIA

  公开号：WO2011056682A1

  公开（公告）日：2011-05-12

  The present invention related to a novel class of zwitterionic lipids that are useful in the preparation of lipid particles suitable for the delivery of encapsulated nucleic acids to cells.

  本发明涉及一种新型的带电离子脂质类物质，可用于制备适用于将封装的核酸传递至细胞的脂质粒子。
• [EN] IMPROVED AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS<br/>[FR] LIPIDES AMINÉS AMÉLIORÉS ET PROCÉDÉS D'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：TEKMIRA PHARMACEUTICALS CORP

  公开号：WO2010042877A1

  公开（公告）日：2010-04-15

  The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

  本发明提供了用于将治疗剂传递给细胞的优越组合物和方法。具体来说，这些包括新型脂质和核酸-脂质颗粒，能够有效地封装核酸并有效地将封装的核酸传递给体内的细胞。本发明的组合物具有高度的效力，因此可以以相对较低的剂量有效地降低特定靶蛋白的表达。此外，本发明的组合物和方法与先前在艺术领域中已知的组合物和方法相比，毒性更低，并提供更大的治疗指数。
• Lipid formulations
  申请人：TEKMIRA PHARMACEUTICALS CORPORATION

  公开号：US09394234B2

  公开（公告）日：2016-07-19

  The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.

  该发明涉及一种具有I式阳离子脂质的改进脂质配方，以及包括I式阳离子脂质的相应使用方法。还公开了靶向脂质和包括这些靶向脂质的特定脂质配方。
• [EN] AMINO LIPID BASED IMPROVED LIPID FORMULATION<br/>[FR] FORMULATION LIPIDIQUE AMÉLIORÉE À BASE D'AMINO LIPIDE
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2009132131A1

  公开（公告）日：2009-10-29

  The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic aicd to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. Formulae (I), (II), (III), (IV).

  本发明提供了将治疗剂传递给细胞的组合物和方法。特别是，这些包括新型脂质和核酸-脂质颗粒，它们能够高效地封装核酸并将封装的核酸有效地传递到体内细胞中。本发明的组合物非常强效，因此可以在相对较低的剂量下有效地降低特定靶蛋白的表达。此外，与先前已知的技术中的组合物和方法相比，本发明的组合物和方法毒性更低，疗效指数更高。公式（I）、（II）、（III）、（IV）。
• WO2008/42973
  申请人：——

  公开号：——

  公开（公告）日：——