N-(β-D-glucopyranosyl)tetradecane-1-carboxamide-14-carboxylic acid | 474938-53-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(β-D-glucopyranosyl)tetradecane-1-carboxamide-14-carboxylic acid
• 英文别名: 16-oxo-16-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]hexadecanoic acid
• CAS: 474938-53-9
• 化学式: C₂₂H₄₁NO₈
• 分子量: 447.569
• InChiKey: XEUBCSDVYOWSIN-RECXWPGBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  31
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)tetradecane-1-carboxamide-14-carboxylic acid 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以99%的产率得到N-(β-D-glucopyranosyl)tetradecane-1-carboxamide-14-carboxylic acid
  参考文献：
  名称：

  NOVEL ASYMMETRICALLY BICIPITAL LIPID AND TUBULAR AGGREGATE FORMED BY USING THE SAME

  摘要：

  公开号：

  EP1396496B1

文献信息

• Novel asymmetrical bicipital lipid and tubular aggregate formed by using the same
  申请人：——

  公开号：US20040120998A1

  公开（公告）日：2004-06-24

  The present invention offers a novel asymmetric double-headed lipid capable of forming a stable, nanometer scale micro-tubular aggregated material of containing a sugar and a carboxylic acid at each end. The present invention is an asymmetric double-headed lipid represented by the general formula R—NHCO—(CH 2 ) n —COOH  (I) (in the formula, R represents an aldopyranose radical from which the terminal reducing hydroxyl group is excluded and n is from six to twenty) and a hollow micro-tubular aggregated material formed from the asymmetric double-headed lipid. The external diameter of the micro-tubular aggregated material is 10-300 nm, and the length is 0.3-10 &mgr;m. The micro-tubular aggregated material can be manufactured by dispersing the asymmetric double-headed lipid described above in water at pH of two to eight, next heating to 80-100° C. to dissolve it and then gradually cooling the aqueous solution obtained.

  本发明提供了一种新型的不对称双头脂质，能够形成稳定的、纳米尺度的微管聚集物，每个末端含有一种糖和一种羧酸。本发明是一种由通式R—NHCO—（CH2）n—COOH表示的不对称双头脂质（在公式中，R代表一个去除末端还原羟基的醛基吡喃糖基团，n为6至20），以及由不对称双头脂质形成的中空微管聚集物。微管聚集物的外径为10-300纳米，长度为0.3-10微米。可以通过在pH为2至8的水中分散上述不对称双头脂质，然后加热至80-100°C以溶解它，最后逐渐冷却所得到的水溶液来制造微管聚集物。
• US6897326B2
  申请人：——

  公开号：US6897326B2

  公开（公告）日：2005-05-24