D-Glucuronlacton-6-<¹⁴C> | 76489-48-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Glucuronlacton-6-<¹⁴C>
• 英文别名: Glucuronolacton；D-Glucuronolacton；D-Glucurono-delta-lactone；(2R,3S,4S,5S)-3,4,5-trihydroxy-6-oxooxane-2-carbaldehyde
• CAS: 76489-48-0
• 化学式: C₆H₈O₆
• 分子量: 176.126
• InChiKey: JBQGSJDKHSBLDG-QTBDOELSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Antihypertensive agents and process for producing the same
  申请人：ZAIDAN HOJIN MINSEI KAGAKU KYOKAI

  公开号：EP0078028A2

  公开（公告）日：1983-05-04

  An aqueous extract product which is effective for prevention or treatment of hypertension is produced by: concentrating an aqueous extract obtained by: extracting water-soluble components from vegetable oils such as soybean oil, corn oil, rapeseed oil and cotton seed oil; adding a lower alcohol to the resulting extract to prepare an alcoholic solution having an alcohol concentration above 85%, thereby precipitating the insoluble matter; then removing the precipitates; and thereafter removing the alcohol. A powdered product having an antihypertensive activity is also produced by: subjecting said aqueous extract product to an additional optional purification step and thereafter concentrating the resulting product to obtain a powder. An antihypertensive agent containing a novel substance OSG as an effective component is also disclosed.

  一种可有效预防或治疗高血压的水提取物产品是通过以下方法制成的：浓缩通过以下方法获得的水提取物：从植物油（如大豆油、玉米油、菜籽油和棉籽油）中提取水溶性成分；向所得提取物中添加低度酒精以制备酒精浓度高于 85% 的酒精溶液，从而沉淀不溶物；然后去除沉淀物；之后去除酒精。 一种具有降压活性的粉末产品也是通过以下方法制成的：将所述水提取物产品进行额外的任选纯化步骤，然后浓缩所得产品以获得粉末。 还公开了一种含有新型物质 OSG 作为有效成分的降压药。
• Oral hygiene compositions
  申请人：JOHNSON & JOHNSON

  公开号：EP0162574A2

  公开（公告）日：1985-11-27

  An oral hygiene composition containing an effective concentration of a pharmaceutically acceptable fluoride salt, a pharmaceutically acceptable zinc salt, a specific buffering agent a suitable vehicle and having a pH of from about 3.5 to 6.0.

  一种口腔卫生组合物，含有有效浓度的药学上可接受的氟盐、药学上可接受的锌盐、特定的缓冲剂和适当的载体，pH 值约为 3.5 至 6.0。
• Physiologically active peptide composition for nasal administration
  申请人：ASAHI KASEI KOGYO KABUSHIKI KAISHA

  公开号：EP0364235A1

  公开（公告）日：1990-04-18

  A powder composition suitable for nasal administration comprising a physiologically active peptide as an active ingredient and a lactone of a water-soluble organic acid as an absorption promoter.

  一种适用于鼻腔给药的粉末组合物，包含作为活性成分的生理活性肽和作为吸收促进剂的水溶性有机酸内酯。
• Extended wear ophthalmic lens
  申请人：Novartis AG

  公开号：EP1043605A1

  公开（公告）日：2000-10-11

  An ophthalmic lens is disclosed which is suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of an oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

  本发明公开了一种眼科镜片，这种镜片适合在眼睛上长时间佩戴至少一天，而不会出现临床上明显的角膜肿胀，也不会使佩戴者感到严重不适。该镜片具有氧气渗透性和离子或水渗透性的平衡，其中离子或水渗透性足以提供良好的眼球运动，从而在镜片和眼睛之间进行良好的泪液交换。一种优选的镜片是氧珀大单体和离子珀单体的共聚产物。本发明包括延戴型隐形眼镜，它包括一个镜芯，镜芯具有从内表面延伸到外表面的氧气传输和离子传输通道。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。