(S)-2-((S)-2-{2-[(4R,5S)-4-Benzyl-2-((S)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-oxazol-5-yl]-acetylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester | 142342-90-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-((S)-2-{2-[(4R,5S)-4-Benzyl-2-((S)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-oxazol-5-yl]-acetylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester
• CAS: 142342-90-3
• 化学式: C₃₆H₅₀N₄O₇
• 分子量: 650.816
• InChiKey: AJEYERLIGNGGAN-JBUMCTQMSA-N

反应信息

• 作为产物：
  描述：

  (S)-2-{(S)-2-[(3S,4S)-4-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-hydroxy-5-phenyl-pentanoylamino]-3-methyl-butyrylamino}-3-methyl-butyric acid methyl ester 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 以58%的产率得到(S)-2-((S)-2-{2-[(4R,5S)-4-Benzyl-2-((S)-1-tert-butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-oxazol-5-yl]-acetylamino}-3-methyl-butyrylamino)-3-methyl-butyric acid methyl ester
  参考文献：
  名称：

  Formation of oxazolines and thiazolines in peptides by the mitsunobu reaction

  摘要：

  The Mitsunobu reaction was efficiently used to introduce oxazolines and thiazolines in the peptide backbone. The reaction proceeded from beta-hydroxy alpha-amino acid-containing peptides at room temperature in 58-72% isolated yields.

  DOI：

  10.1016/s0040-4039(00)78864-2