Sodium;[2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxoxanthen-4-yl]mercury;hydrate | 129-16-8

• 物质功能分类: 原料药 - 人工合成抗感染类药 - 消毒防腐药
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Sodium;[2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxoxanthen-4-yl]mercury;hydrate
• 英文别名: sodium;[2,7-dibromo-9-(2-carboxyphenyl)-3-hydroxy-6-oxoxanthen-4-yl]mercury;hydrate
• CAS: 129-16-8
• 化学式: C20H11Br2HgNaO6+
• 分子量: 730.7
• InChiKey: QJJYLIJNUFJILQ-UHFFFAOYSA-N

物化性质

• 熔点：
  ≥300 °C
• 溶解度：
  水：≥ 50 mg/mL (66.43 mM)；DMSO：6.67 mg/mL (8.86 mM)
• LogP：
  1.418 at 25℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.8
• 氢给体数：
  3
• 氢受体数：
  6

ADMET

毒理性

• 人类毒性摘录

我们回顾了过去6年在儿科过敏咨询室所见到的药物过敏反应。在此期间，对疑似药物不良反应的840名患者进行了检查。确认药物过敏72例（8.5%）。在这些病例中，29例（40.2%）被认为是IgE介导的，或即时超敏反应。我们没有发现与年龄、性别、家族过敏史或过敏症在IgE介导反应的患者与不同机制过敏药物反应的患者或无药物过敏的患者之间有显著差异。在非即时反应中，磺胺类药物引起的固定药疹和汞红引起的接触性皮炎最为常见。

We present a retrospective study of allergic drug reactions seen in our pediatric allergy consulting room during the last 6 years. During this time, 840 patients were examined for suspected adverse drug reactions. Drug allergy was confirmed in 72 cases (8.5%). Of these cases, 29 (40.2%) were considered to be IgE mediated, or immediate hypersensitivity reactions. We have not found significant differences with regards to age, sex, atopic family history or atopia between patients with IgE mediated reactions compared to patients with allergic drug reactions of different mechanisms or to patients without drug allergies. Among non-immediate reactions, fixed eruption by sulfonamides and contact dermatitis due to mercurochrome were the most frequent.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

水银化合物是已知的过敏性接触性皮炎的常见原因。水银有机衍生物很少引起即时超敏反应。然而，已发布的病例中没有一个同时表现出即时和延迟超敏反应，就像我们两个病人中的一个那样。一名男孩和一名妇女在局部应用Merchromine（Merbromine）/红药水/后分别出现了荨麻疹和过敏性休克。我们能够通过皮肤测试和组胺释放证明两个患者对荧光素化合物的即时超敏反应。此外，这名儿童但不是这名妇女，对水银化合物显示出延迟超敏反应。

Mercurial compounds are known to be a common cause of allergic contact dermatitis. Immediate hypersensitivity is rarely induced by mercurial organic derivatives. However, none of the published cases showed both immediate and delayed hypersensitivity as was the case of one of our two patients. A boy and a woman experienced urticaria and anaphylaxis, respectively after topical application of Merchromine (Merbromine) /mercurochrome/. We were able to demonstrate immediate hypersensitivity in both patients to mercuric fluorescein compounds by skin test and histamine liberation. In addition, the child but not the woman, showed delayed hypersensitivity to mercurial compounds.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

通过使用皮内测试、被动转移和体外组胺释放测试，我们能够证明一位年轻男子对含汞消毒剂汞红产生了即时超敏反应，他在接触这种消毒剂后遭受了过敏性休克。还观察到了不同有机汞化合物之间的交叉反应。

By the use of intradermal tests, passive transfer, and an in vitro histamine release test, we were able to demonstrate immediate hypersensitivity to mercurochrome in a young man who had suffered anaphylactic shock after having contact with this antiseptic. Cross-reactions among different organic mercurial compounds were observed.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

我们回顾了过去6年在儿科过敏咨询室所见到的药物过敏反应。在此期间，对疑似药物不良反应的840名患者进行了检查。确认了72例药物过敏（占8.5%）。在这些病例中，29例（占40.2%）被认为是IgE介导的，或即时超敏反应。我们没有发现与年龄、性别、家族过敏史或变态反应有关的显著差异，IgE介导反应的患者与不同机制过敏药物反应的患者或无药物过敏的患者相比。在非即时反应中，磺胺类药物引起的固定药疹和由于汞红引起的接触性皮炎最为常见。

We present a retrospective study of allergic drug reactions seen in our pediatric allergy consulting room during the last 6 years. During this time, 840 patients were examined for suspected adverse drug reactions. Drug allergy was confirmed in 72 cases (8.5%). Of these cases, 29 (40.2%) were considered to be IgE mediated, or immediate hypersensitivity reactions. We have not found significant differences with regards to age, sex, atopic family history or atopia between patients with IgE mediated reactions compared to patients with allergic drug reactions of different mechanisms or to patients without drug allergies. Among non-immediate reactions, fixed eruption by sulfonamides and contact dermatitis due to mercurochrome were the most frequent.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

水银化合物是已知的过敏性接触性皮炎的常见原因。水银有机衍生物很少引起即时超敏反应。然而，已发布的病例中没有一个同时表现出即时和延迟超敏反应，就像我们两个病人中的一个那样。一名男孩和一名妇女在局部应用Merchromine（Merbromine）/红药水/后分别出现了荨麻疹和过敏性休克。我们能够通过皮肤测试和组胺释放证明两个患者对荧光素化合物的即时超敏反应。此外，这名儿童但不是这名妇女，对水银化合物显示出延迟超敏反应。

Mercurial compounds are known to be a common cause of allergic contact dermatitis. Immediate hypersensitivity is rarely induced by mercurial organic derivatives. However, none of the published cases showed both immediate and delayed hypersensitivity as was the case of one of our two patients. A boy and a woman experienced urticaria and anaphylaxis, respectively after topical application of Merchromine (Merbromine) /mercurochrome/. We were able to demonstrate immediate hypersensitivity in both patients to mercuric fluorescein compounds by skin test and histamine liberation. In addition, the child but not the woman, showed delayed hypersensitivity to mercurial compounds.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 危险品标志：
  T+,N
• 安全说明：
  S13,S28,S36,S45,S60,S61
• 危险类别码：
  R33,R50/53,R26/27/28
• WGK Germany：
  3
• 危险品运输编号：
  UN 2025
• RTECS号：
  LM5250000
• 包装等级：
  II
• 危险类别：
  6.1(a)

制备方法与用途

生物活性

Merbromin 用作割伤和擦伤的局部消毒剂，同时也作为一种生物染料。研究显示，Merbromin 能有效抑制寨卡病毒 (ZIKV) 的复制，并通过抑制 ZIKVpro 表现出抗 ZIKV 效力。

用途

Merbromin 主要用于医药领域的外用消毒剂以及化工产品的原料。

类别

有毒物质

毒性分级

中毒

急性毒性

腹腔-小鼠 LD50: 200 毫克/公斤

可燃性危险特性

Merbromin 具有可燃性，火场会产生含汞、溴化物和氧化钠的辛辣刺激烟雾。

储运特性

库房应低温、通风且干燥保存。

灭火剂

使用水、二氧化碳、干粉或砂土灭火。