1-(1-{2-[3-(2,2-dimethylpropanoyl)-6-phenyl-1,3-oxazinan-6-yl]ethyl}piperidin-4-yl)-1H-indole | 716324-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(1-{2-[3-(2,2-dimethylpropanoyl)-6-phenyl-1,3-oxazinan-6-yl]ethyl}piperidin-4-yl)-1H-indole
• 英文别名: 1-[6-[2-(4-Indol-1-ylpiperidin-1-yl)ethyl]-6-phenyl-1,3-oxazinan-3-yl]-2,2-dimethylpropan-1-one
• CAS: 716324-08-2
• 化学式: C₃₀H₃₉N₃O₂
• 分子量: 473.659
• InChiKey: PRKXIUGINCHYAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AS CCR5 ANTAGONISTS<br/>[FR] COMPOSES HETEROCYCLIQUES UTILISES EN TANT QU'ANTAGONISTES DU CCR5
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004055011A1

  公开（公告）日：2004-07-01

  The present invention relates to compounds of the following formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

  本发明涉及以下式(I)的化合物，或其药学上可接受的衍生物，在CCR5相关疾病和疾病的治疗中有用，例如，在抑制HIV复制、预防或治疗HIV感染以及治疗由此导致的获得性免疫缺陷综合症（AIDS）方面有用。
• Heterocyclic compounds as ccr5 antagonists
  申请人：Aquino Joseph Christopher

  公开号：US20060052595A1

  公开（公告）日：2006-03-09

  The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

  本发明涉及公式（I）的化合物或其药学上可接受的衍生物，用于治疗CCR5相关疾病和障碍，例如，在抑制HIV复制方面有用，预防或治疗HIV感染，并用于治疗由此导致的获得性免疫缺陷综合症（AIDS）。
• HETEROCYCLIC COMPOUNDS AS CCR5 ANTAGONISTS
  申请人：AQUINO Christopher Joseph

  公开号：US20090053172A1

  公开（公告）日：2009-02-26

  The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

  本发明涉及式(I)化合物或其药学上可接受的衍生物，用于治疗CCR5相关的疾病和障碍，例如，用于抑制HIV复制，预防或治疗HIV感染，并用于治疗由此导致的获得性免疫缺陷综合症（AIDS）。
• EP1569931B1
  申请人：——

  公开号：EP1569931B1

  公开（公告）日：2008-10-08
• US7452992B2
  申请人：——

  公开号：US7452992B2

  公开（公告）日：2008-11-18