tert-butyl 2-(5-chloro-1H-indol-3-yl)-2-(hydroxyamino)ethylcarbamate | 1309463-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: tert-butyl 2-(5-chloro-1H-indol-3-yl)-2-(hydroxyamino)ethylcarbamate
• 英文别名: tert-butyl N-[2-(5-chloro-1H-indol-3-yl)-2-(hydroxyamino)ethyl]carbamate
• CAS: 1309463-96-4
• 化学式: C₁₅H₂₀ClN₃O₃
• 分子量: 325.795
• InChiKey: NYXWAYFVWRGBAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  86.4
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-(5-chloro-1H-indol-3-yl)-2-(hydroxyamino)ethylcarbamate 在 titanium(III) chloride 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 0.5h， 生成 tert-butyl (2-(5-chloro-1H-indol-3-yl)-2-(5-chloro-1H-indole-3-carboxamido)ethyl)carbamate
  参考文献：
  名称：

  [EN] BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG
  [FR] DÉRIVÉS BIS-INDOLIQUES, PROCÉDÉ POUR PRÉPARER CEUX-CI ET LEURS UTILISATIONS EN TANT QUE MÉDICAMENT

  摘要：

  本发明涉及新型双吲哚衍生物、其制备方法以及它们作为新型抗菌药物的潜在用途。

  公开号：

  WO2013014102A1
• 作为产物：
  描述：

  tert-butyl 2-(benzyl(hydroxy)amino)-2-(1H-indol-3-yl)ethylcarbamate 在 甲醇 、 manganese(IV) oxide 、 盐酸羟胺 、 乙酰氯 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 3.08h， 生成 tert-butyl 2-(5-chloro-1H-indol-3-yl)-2-(hydroxyamino)ethylcarbamate
  参考文献：
  名称：

  Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents

  摘要：

  A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.03.060

文献信息

• [EN] BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS<br/>[FR] DÉRIVÉS BIS-INDOLIQUES, LEURS UTILISATIONS EN PARTICULIER EN TANT QU'ANTIBACTÉRIENS
  申请人：UNIV JOSEPH FOURIER

  公开号：WO2013014104A1

  公开（公告）日：2013-01-31

  The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

  本发明涉及新型双吲哚衍生物，其制备方法以及作为新型抗菌药物的潜在用途。
• Novel bis-indolic derivatives, their uses in particular as antibacterials
  申请人：Université Joseph Fourier

  公开号：EP2548865B1

  公开（公告）日：2014-03-05
• [EN] BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG<br/>[FR] DÉRIVÉS BIS-INDOLIQUES, PROCÉDÉ POUR PRÉPARER CEUX-CI ET LEURS UTILISATIONS EN TANT QUE MÉDICAMENT
  申请人：UNIV JOSEPH FOURIER

  公开号：WO2013014102A1

  公开（公告）日：2013-01-31

  The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

  本发明涉及新型双吲哚衍生物、其制备方法以及它们作为新型抗菌药物的潜在用途。
• Synthesis and evaluation of 1-(1H-indol-3-yl)ethanamine derivatives as new antibacterial agents
  作者：Olga N. Burchak、Emmanuelle Le Pihive、Laure Maigre、Xavier Guinchard、Pascale Bouhours、Claude Jolivalt、Dominique Schneider、Max Maurin、Carmela Giglione、Thierry Meinnel、Jean-Marc Paris、Jean-Noël Denis

  DOI：10.1016/j.bmc.2011.03.060

  日期：2011.5

  A collection of 3-substituted indole derivatives was prepared using nucleophilic addition of indoles to nitrones. The compounds were then tested for their antibacterial activity against almost thirty bacterial strains representative of common human pathogens. Two types of indolic molecules inhibit the growth of Staphylococcus aureus, including MRSA and VISA strains, with MIC values ranging from 8 to 16 mg/L. (C) 2011 Elsevier Ltd. All rights reserved.