8-methoxy-4-methyl-2-propyl-4,5-dihydro-1H-2-benzazepin-3-one | 1173893-68-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 8-methoxy-4-methyl-2-propyl-4,5-dihydro-1H-2-benzazepin-3-one
• CAS: 1173893-68-9
• 化学式: C₁₅H₂₁NO₂
• 分子量: 247.337
• InChiKey: CYANSHQDJQAADI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  8-Methoxy-4-methyl-1,2,4,5-tetrahydro-2-benzazepin-3-one 、 1-碘代丙烷 在 18-冠醚-6 、 双(三甲基硅烷基)氨基钾 作用下， 以 四氢呋喃 为溶剂， 以72%的产率得到8-methoxy-4-methyl-2-propyl-4,5-dihydro-1H-2-benzazepin-3-one
  参考文献：
  名称：

  An efficient preparation of N-alkyl-2-benzazepine derivatives and investigation of their biological activity

  摘要：

  N-Alkyl-2-benzazepine derivatives are readily prepared through N-alkylation of secondary 2-benzazepines that are constructed via 7-endo selective cyclization of radical cyclization of N-boc-N-(2-bromo5-methoxyphenylmethyl) methacrylamides. The structure and activity relationship of these derivatives are examined. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.117

文献信息

• An efficient preparation of N-alkyl-2-benzazepine derivatives and investigation of their biological activity
  作者：Akio Kamimura、Masahiro So、Tomohiro Kuratani、Kenji Matsuura、Makoto Inui

  DOI：10.1016/j.bmcl.2009.04.117

  日期：2009.6

  N-Alkyl-2-benzazepine derivatives are readily prepared through N-alkylation of secondary 2-benzazepines that are constructed via 7-endo selective cyclization of radical cyclization of N-boc-N-(2-bromo5-methoxyphenylmethyl) methacrylamides. The structure and activity relationship of these derivatives are examined. (C) 2009 Elsevier Ltd. All rights reserved.