(Z)-5-chloro-3-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)hydrazono)indolin-2-one | 1401343-94-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-5-chloro-3-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)hydrazono)indolin-2-one
• 英文别名: 3-[2-(5-chloro-2-oxoindol-3-yl)hydrazinyl]-5-fluoroindol-2-one
• CAS: 1401343-94-9
• 化学式: C₁₆H₈ClFN₄O₂
• 分子量: 342.717
• InChiKey: BLYKGZSPMFXAML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel N, N'-Hydrazino-bis-isatin Derivatives with Selective Activity Against Multidrug-Resistant Cancer Cells
  申请人：Mohamed Hassan Tarek Aboul-Fadl

  公开号：US20120252860A1

  公开（公告）日：2012-10-04

  The invention is directed to a compound of Formula (I), wherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R 1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C 1 -C 4 alkyl group, nitro group, and —OCF 3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.

  本发明涉及一种式（I）的化合物，其中R选自氢原子和未取代或取代的苯基团组成的群；R1选自氢原子和未取代或取代的苯基团组成的群；X选自氢原子或卤素原子；Y选自氢原子、卤素原子、C1-C4烷基、硝基和—OCF3基团组成的群。该化合物被用于治疗，特别是用于治疗癌症，并且涉及相关的制药组合物、用于制造相应医疗适应症药物的化合物的使用以及制备该化合物的合成方法。
• Novel N,N'-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
  申请人：King Saud University

  公开号：EP2508512B1

  公开（公告）日：2013-07-31
• US8497296B2
  申请人：——

  公开号：US8497296B2

  公开（公告）日：2013-07-30