1-hydroxy-2,8-diphenyl-4,11,16-trioxa-17-oxopentacyclo<8.5.1.2^8,15.0^3,8.0^10,15>octadecane | 139690-12-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-hydroxy-2,8-diphenyl-4,11,16-trioxa-17-oxopentacyclo<8.5.1.2^8,15.0^3,8.0^10,15>octadecane
• CAS: 139690-12-3
• 化学式: C₂₆H₂₆O₅
• 分子量: 418.489
• InChiKey: HDZHUEUHAJSTKU-FSPWKIDPSA-N

反应信息

• 作为产物：
  描述：

  8-phenyl-8-chloro-2-oxa-cis-bicyclo<4.2.0>octan-7-one 在 lithium perchlorate 、 三乙胺 作用下， 以 水 、 乙腈 为溶剂， 反应 0.5h， 以10%的产率得到9,16-diphenyl-15-hydroxy-2,4,11-trioxa-17-oxopentacyclo<6.6.3.0^1,10.0^9,15.0^3,8>heptadecane
  参考文献：
  名称：

  Proximity effects in fused cyclobutanones. Facile formation of cage systems

  摘要：

  Chlorbicyclooctanone 3 on reaction with H2O-Et3N in acetonitrile at 20-degrees-C produced in high yield four complex dimeric compounds 4-7. The novel structures produced by C-C bond formation between tertiary centers were revealed by NMR and X-ray diffraction. Pathways leading from 4 or its diastereomer 14 to cage compounds 5-7 indicate the importance of proximity effects in these transformations.

  DOI：

  10.1021/jo00034a045