2,4-Bis(4-methoxyphenyl)-1,3,2lambda~5~,4lambda~5~-dithiadiphosphetane-2,4-dione | 125271-54-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-Bis(4-methoxyphenyl)-1,3,2lambda~5~,4lambda~5~-dithiadiphosphetane-2,4-dione
• 英文别名: 2,4-bis(4-methoxyphenyl)-1,3,2λ5,4λ5-dithiadiphosphetane 2,4-dioxide
• CAS: 125271-54-7
• 化学式: C₁₄H₁₄O₄P₂S₂
• 分子量: 372.3
• InChiKey: SGDYYICUHKZAIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] ALDOSTERONE SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS D'ALDOSTÉRONE SYNTHASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2012148808A1

  公开（公告）日：2012-11-01

  This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

  本发明涉及式I的三环三唑类似物或其药用可接受的盐，其中变量如本文所述定义。本发明的化合物选择性地抑制醛固酮合成酶。本发明还提供了包含式I化合物或其盐的药物组合物，以及用于治疗、改善或预防可以通过抑制醛固酮合成酶来治疗的疾病的方法。
• [EN] PESTICIDAL COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS PESTICIDES ET LEURS UTILISATIONS
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2017093409A1

  公开（公告）日：2017-06-08

  The present invention concerns certain cyclic derivatives of guanidine compounds and their use in protecting plants, their use to control mosquitoes, and vector control management methods or control solutions comprising such a cyclic derivative of guanidine compounds, in particular the invention relates to a substrate, to a composition, comprising a cyclic derivative of guanidine compounds for controlling mosquitoes.

  本发明涉及特定的胍基化合物的环状衍生物及其在保护植物、控制蚊虫以及含有该胍基化合物环状衍生物的向量控制管理方法或控制溶液中的应用，具体而言，该发明涉及一种基质，一种包含胍基化合物环状衍生物的组合物，用于控制蚊虫。
• ALDOSTERONE SYNTHASE INHIBITORS
  申请人：Hoyt Scott B.

  公开号：US20140045819A1

  公开（公告）日：2014-02-13

  This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

  本发明涉及公式I的三环三唑类似物或其药学上可接受的盐，其中变量在此定义。这些创新化合物选择性地抑制醛固酮合成酶。本发明还提供了包含公式I的化合物或其盐的药物组合物，以及用于治疗、改善或预防通过抑制醛固酮合成酶可治疗的疾病的方法。
• [DE] SUBSTITUIERTE N-PHENYLGLUTARIMIDE UND N-PHENYLGLUTARSÄUREAMIDE, DEREN HERSTELLUNG UND VERWENDUNG IN DER LANDWIRTSCHAFT<br/>[EN] SUBSTITUTED N-PHENYLGLUTARIMIDES AND N-PHENYLGLUTARIC ACID AMIDES, THEIR PREPARATION AND USE IN AGRICULTURE<br/>[FR] N-PHENYLGLUTARIMIDES SUBSTITUES ET AMIDES D'ACIDE N-PHENYLGLUTARIQUE, LEUR PREPARATION ET LEUR UTILISATION DANS L'AGRICULTURE
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：WO1994010147A1

  公开（公告）日：1994-05-11

  (DE) Substituiertes N-Phenylglutarimide (I), worin X1, X2 = O, S; R1 = Halogen, NO2, CN, CF3; R2 = H, Halogen; R3, R4, R5 = H, Halogen, CN, Alkyl, Cycloalkyl, Alkenyl, Alkinyl, Halogenalkyl, Alkoxy, Halogenalkoxy, Alkylthio, Halogenalkylthio, Cyanoalkyl, Alkoxycarbonyl, ggf. substituiertes Phenyl oder Benzyl, oder 2 Substituenten eines C-Atoms des Glutarimidrings sind über eine ggf. substituierte Kette miteinander verbunden, oder 2 Substituenten benachbarter C-Atome des Glutarimidrings sind über eine ggf. substituierte Kette miteinander verbunden; A = CHR6-CHR7-CO-B oder CR6=CR8-CO-B; R6 = H, C1-C6-Alkyl oder C1-C6-Halogenalkyl; R7 = Halogen, Halogenalkyl, OH, Alkoxy oder Alkylcarbonyloxy; R8 = H, Halogen, CN, Alkyl, Halogenalkyl, OH, Alkoxy, Alkylcarbonyl, Alkoxycarbonyl oder Alkylcarbonyloxy; B = H, Alkyl, Alkenyl, Alkinyl, Halogenalkyl, Cycloalkyl, Alkoxyalkyl, Dialkoxyalkyl, Alkylthioalkyl, OR9, SR9, NR10, R11; R9 = H, Alkyl, Alkenyl, Alkinyl, Cycloalkyl, Halogenalkyl, Cyanoalkyl, Halogenalkenyl, Alkoxycarbonylalkyl, Alkoxyalkyl, Alkylthioalkyl, Alkylimino, Alkyloximinoalkyl, ggf. substituiertes Phenyl oder Benzyl; R10, R11 = H, Alkyl, Alkenyl, Alkinyl, Cycloalkyl, Halogenalkyl, Alkylcarbonyl, Alkoxycarbonyl, Alkoxyalkyl, ggf. substituiertes Phenyl, oder R10 und R11 zusammen mit dem gemeinsamen N-Atom = gesättigter oder ungesättigter 4- bis 7-gliedriger Heterocyclus mit 1-2 weiteren Heteroatomen, sowie pflanzenverträgliche Salze von (I); deren Herstellung und Verwendung als Herbizide und Desikkations-/Defolationsmittel, sowie Vorprodukte zur Herstellung der N-Phenylglutarimide (I).(EN) Substituted N-phenylglutarimides (I), wherein X1, X2 = O, S; R1 = halogen, NO2, CN, CF3; R2 = H, halogen; R3, R4, R5 = H, halogen, CN, alkyl, cycloalkyl, alkenyl, alkinyl, alkyl halide, alkoxy, alkoxy halide, alkyl thio, alkyl thio halide, cyanoalkyl, alkoxy carbonyl, possibly substituted phenyl or benzyl, or 2 substituents of a C atom of the glutarimide ring are linked via a possibly substituted chain, or 2 substituents of adjacent C atoms of the glutarimide ring are linked via a possibly substituted chain; A = CHR6-CHR7-CO-B or CR6=CR8-CO-B; R6 = H, C1-C6-alkyl or C1-C6-alkyl halide; R7 = halogen, alkyl halide, OH, alkoxy or alkyl carbonyl alkoxy; R8 = H, halogen, CN, alkyl, alkyl halide, OH, alkoxy, alkyl carbonyl, alkoxy carbonyl or alkyl carbonyloxy; B = H, alkyl, alkenyl, alkinyl, alkyl halide, cycloalkyl, alkoxy alkyl, dialkoxy alkyl, alkyl thioalkyl, OR9, SR9, NR10, R11; R9 = H, alkyl, alkenyl, alkinyl, cycloalkyl, alkyl halide, cyanoalkyl, alkenyl halide, alkoxy carbonyl alkyl, alkoxyalkyl, alkyl thioalkyl, alkylimino, alkylimino alkyl, possibly substituted phenyl or benzyl; R10, R11 = H, alkyl, alkenyl, alkinyl, cycloalkyl, alkyl halide, alkyl carbonyl, alkoxy carbonyl, alkoxy alkyl, possibly substituted phenyl, or R10 und R11 together with the common N atom = saturated or unsaturated 4- to 7- membered heterocycle with 1-2 other heteroatoms, as well as salts of (I) that are tolerable to plants; their preparation and use as herbicides and desiccants/defoliants, as well as preproducts for preparing the N-phenylglutarimides (I).(FR) L'invention concerne des N-phénylglutarimides substitués (I), où X1, X2 = O, S; R1 = halogène, NO2, CN, CF3; R2 = H, halogène; R3, R4, R5 = H, halogène, CN, alkyle, cycloalkyle, alcényle, alkinyle, halogénure d'alkyle, alcoxy, halogénure d'alcoxy, alkylthio, halogénure d'alkylthio, cyanoalkyle, alcoxycarbonyle, phényle or benzyle éventuellement substitué, ou bien 2 substituats d'un carbone de C du composé cyclique glutarimide qui sont liés par l'intermédiaire d'une chaîne éventuellement substituée, ou bien 2 substituants d'atomes de C adjacents du composé cyclique glutarimide qui sont liés par l'intermédiaire d'une chaîne éventuellement substituée; A = CHR6-CHR7-CO-B ou CR6=CR8-CO-B; R6 = H, alkyle C1-C6 ou halogénure d'alkyle C1-C6; R7 = halogène, halogénure d'alkyle, OH, alcoxy ou alkylcarbonyloxy; R8 = H, halogène, CN, alkyle, halogénure d'alkyle, OH, alcoxy, alkylcarbonyle ou alkylcarbonyloxy; B = H, alkyle, alcényle, alkinyle, halogénure d'alkyle, cycloalkyle, alcoxyalkyle, dialcoxyalkyle, alkylthioalkyle, OR9, SR9, NR10, R11; R9 = H, alkyle, alcényle, alkinyle, cycloalkyle, halogénure d'alkyle, cyanoalkyle, halogénure d'alcényle, alcoxycarbonylalkyle, alcoxyalkyle, alkylthioalkyle, alkylimino, alkyloxyminoalkyle, phényle ou benzyle éventuellement substitué; R10, R11 = H, alkyle, alcényle, alkinyle, cycloalkyle, halogénure d'alkyle, alkylcarbonyle, alcoxycarbonyle, alcoxyalkyle, phényle éventuellement substitué, ou R10 et R11 conjointement avec l'atome de N commun = hétérocycle saturé ou insaturé ayant entre 4 et 7 chaînons, avec 1 à 2 autres hétéroatomes, ainsi que des sels de (I) non phytotoxiques; leur préparation et leur utilisation comme herbicides et siccatifs/défoliants, ainsi que des produits initiaux utilisés pour préparer des N-phénylglutarimides (I).

  该发明涉及一种被取代的N-苯基 glutarimide (I)，其中X1、X2 = O、S；R1 =卤素、NO2、CN、CF3；R2 = H、卤素；R3、R4、R5 = H、卤素、CN、 alkyl、cycloalkyl、 alkenyl、 alkinyl、 alkyl halide、 alkoxy、 alkoxy halide、 alkyl thio、 alkyl thio halide、 cyanoalkyl、 alkoxy carbonyl、可能被取代的苯或苯甲基，或者位于 glutarimide 环的C原子上的两个取代基通过一条可能被取代的链连接，或者位于 glutarimide 环相邻C原子上的两个取代基通过一条可能被取代的链连接；A = CHR6-CHR7-CO-B 或 CR6=CR8-CO-B；R6 = H、C1-C6-alkyl 或 C1-C6-alkyl halide；R7 =卤素、alkyl halide、OH、alkoxy 或 alkyl carbonyl alkoxy；R8 = H、卤素、CN、alkyl、 alkyl halide、OH、alkoxy、 alkylcarbonyl、 alkoxy carbonyl 或 alkyl carbonyloxy；B = H、alkyl、 alkenyl、 alkinyl、 alkyl halide、 cycloalkyl、 alkoxy alkyl、 dialkoxy alkyl、 alkyl thioalkyl、 OR9、 SR9、 NR10、 R11；R9 = H、 alkyl、 alkenyl、 alkinyl、 cycloalkyl、 alkyl halide、 cyanoalkyl、 alkenyl halide、 alkoxy carbonyl alkyl、 alkoxy alkyl、 alkyl thioalkyl、 alkylimino、 alkylimino alkyl、可能被取代的苯或苯甲基；R10、R11 = H、 alkyl、 alkenyl、 alkinyl、 cycloalkyl、 alkyl halide、 alkyl carbonyl、 alkoxy carbonyl、 alkoxy alkyl、可能被取代的苯、或者 R10 和 R11 一起与共同的N原子一起 = 满足4到7个碳链且可能含有1到2个其他heteroatoms的饱和或不饱和的heterocycle，以及与(I)反应的植物相容的盐。
• Methods for minimizing thioamide impurities
  申请人：Wilk Kazimierz Bogdan

  公开号：US20080071083A1

  公开（公告）日：2008-03-20

  Methods for minimizing the formation of thioamide compounds using decoy agents during reactions, such as thionations of carbonyl compounds containing nitrile groups, and the products thereby are provided.