[Cu(N,N'-bis-pyridin-2-ylmethyl-butane-1,4-diimine)](ClO4)2 | 949001-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: [Cu(N,N'-bis-pyridin-2-ylmethyl-butane-1,4-diimine)](ClO4)2
• CAS: 949001-29-0
• 化学式: C₁₆H₁₈ClCuN₄O₄*C₁₆H₁₈Cl₂CuN₄O₈*ClO₄
• 分子量: 1057.59
• InChiKey: IZZQDHLGOHCAAM-GDITVVAMSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 copper(II) perchlorate 、 四亚甲基二胺 以 甲醇 为溶剂， 生成 [Cu(N,N'-bis-pyridin-2-ylmethyl-butane-1,4-diimine)](ClO4)2
  参考文献：
  名称：

  Copper(II) complexes of N4 tetradentate ligands with flexible alkyl spacers: Crystal structure, DNA binding and cleavage studies

  摘要：

  Mononuclear copper(II) complexes, [Cu L1] (CIO4)2 (1), [CU L2] (ClO4)2 (2) and [Cu L3] (ClO4)2 (3) with quadridentate Schiff base ligands Ll (N,N'-bis-pyridin-2-ylmethyl-butane-1,4-diimine), L2 (NN'-bis-pyridin-2-ylmethyl-pentane-1,5-diimine) and L3 (NA7-bis-pyridin-2-ylmethyl-hexane-1,6-diimine) have been synthesized and characterized. The crystal structure data of I reveals the existence of the complex in two different geometries, namely a square pyramid and a distorted octahedron, which eventually leads to the packing of the molecule into helical and anti-parallel structures respectively. Absorption titration studies with calf thymus DNA for all three complexes are suggestive of groove binding with binding constant values for 1, 2 and 3 being 2.6 0.2 x ()4 M- 1, 11.5:+/- 0.2 x 104 M-1 and 1.83 0.2 x 104 M-1 respectively. Control cleavage experiments using pBR 322 plasmid DNA and distamycin suggest minor groove binding for these complexes. In the presence of ascorbic acid, the complexes show efficient DNA cleavage, the order of efficiency being 1 > 2=3. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2007.02.020