(S)-p-(4-hydroxybenzoyl)phenylalanine | 213668-29-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-p-(4-hydroxybenzoyl)phenylalanine
• 英文别名: 4-(4-Hydroxybenzoyl)-L-phenylalanine；(2S)-2-amino-3-[4-(4-hydroxybenzoyl)phenyl]propanoic acid
• CAS: 213668-29-2
• 化学式: C₁₆H₁₅NO₄
• 分子量: 285.299
• InChiKey: MHNWMIBIJOTAQH-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-2-Amino-3-[4-(4-benzyloxy-benzoyl)-phenyl]-propionic acid; hydrochloride 在 palladium on activated charcoal sodium hydroxide 、 氢气 作用下， 反应 1.5h， 生成 (S)-p-(4-hydroxybenzoyl)phenylalanine
  参考文献：
  名称：

  Synthesis of (S)- and (R)-enantiomers of p-(4-hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide–protein binding sites

  摘要：

  A high yield, multigram synthesis of both enantiomers of p-(4-hydroxybenzoyl)phenylalanine, cross-linking probes for peptide-protein binding interactions, is reported. The synthesis was accomplished using Schollkopf chiral auxiliary reagents. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00229-8

文献信息

• Photolabeling reagent
  申请人：President and Fellows of Harvard College

  公开号：US05986136A1

  公开（公告）日：1999-11-16

  Disclosed is a compound represent by the following structural formula: ##STR1## X is --H or an amine protecting group; --OY is --OH, an activating group for a carboxylic acid or a protecting group for a carboxylic acid; Z is --H or a phenolic protecting group, with the proviso that Z is not a straight chained, unsaturated alkyl group such as, for example, methyl or ethyl, and at least one of X, Y or Z is not --H. Also disclosed is a photoreactive polypeptide having a polypeptide chain comprising a residue of the compound described above. Also disclosed is a method of labeling a target molecule which forms a complex with the photoreactive polypolypeptide by photolyzing the photoreactive polypeptide when complexed with the target molecule.

  本发明涉及一种由以下结构式表示的化合物：##STR1## 其中，X是--H或氨基保护基；--OY是--OH，用于激活羧酸或保护羧酸的保护基；Z是--H或酚保护基，但Z不是直链不饱和烷基，例如甲基或乙基，并且X、Y或Z中至少有一个不是--H。本发明还涉及一种光反应性多肽，其具有包含上述化合物残基的多肽链。本发明还涉及一种通过光解与靶分子形成复合物的光反应性多肽标记靶分子的方法。
• N-DEMETHYASE GENES AND USES THEREOF
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：US20140227729A1

  公开（公告）日：2014-08-14

  The invention provides isolated nucleic acid encoding one or more gene products that allow for degradation of caffeine and related structures, and for preparation of intermediates in that catabolic pathway. Further provided are methods of using one or more of those gene products.

  本发明提供了编码一种或多种基因产物的分离核酸，该基因产物允许咖啡因及相关结构的降解，并用于该分解途径中间体的制备。此外，还提供了使用其中一种或多种基因产物的方法。
• CAFFEINE RESPONSIVE PROMOTERS AND REGULATORY GENES
  申请人：Uinversity of Iowa Research Foundation

  公开号：US20150184166A1

  公开（公告）日：2015-07-02

  The invention provides isolated N-demethylase genes and caffeine responsive proteins.

  本发明提供了分离的N-去甲基化酶基因和咖啡因响应蛋白。
• Synthetic oplophorus luciferases with enhanced light output
  申请人：Promega Corporation

  公开号：US10233485B2

  公开（公告）日：2019-03-19

  A polynucleotide encoding a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type Oplophorus luciferase and includes at least one amino acid substitution at a position corresponding to an amino acid in a wild-type Oplophorus luciferase of SEQ ID NO:1. The modified luciferase polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the wild-type Oplophorus luciferase.

  一种编码修饰荧光素酶多肽的多核苷酸。修饰的荧光素酶多肽与野生型Oplophorus荧光素酶至少有60%的氨基酸序列相同性，并在与SEQ ID NO:1的野生型Oplophorus荧光素酶中的氨基酸相对应的位置上包括至少一个氨基酸替换。相对于野生型Oplophorus荧光素酶，修饰的荧光素酶多肽具有增强的发光、增强的信号稳定性和增强的蛋白质稳定性中的至少一种。
• Synthetic Oplophorus luciferases with enhanced light output
  申请人：Promega Corporation

  公开号：US10844422B2

  公开（公告）日：2020-11-24

  A polynucleotide encoding a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type Oplophorus luciferase and includes at least one amino acid substitution at a position corresponding to an amino acid in a wild-type Oplophorus luciferase of SEQ ID NO:1. The modified luciferase polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the wild-type Oplophorus luciferase.

  一种编码修饰荧光素酶多肽的多核苷酸。修饰的荧光素酶多肽与野生型Oplophorus荧光素酶至少有60%的氨基酸序列相同性，并在与SEQ ID NO:1的野生型Oplophorus荧光素酶中的氨基酸相对应的位置上包括至少一个氨基酸替换。相对于野生型Oplophorus荧光素酶，修饰的荧光素酶多肽具有增强的发光、增强的信号稳定性和增强的蛋白质稳定性中的至少一种。