N-propan-2-ylpent-4-enamide | 1367872-14-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-propan-2-ylpent-4-enamide
• CAS: 1367872-14-7
• 化学式: C₈H₁₅NO
• mdl: MFCD24392392
• 分子量: 141.213
• InChiKey: GISYLYGFGLICKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-propan-2-ylpent-4-enamide 在 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 24.33h， 生成 O-ethyl S-((1-isopropyl-5-oxopyrrolidin-2-yl)methyl) carbonodithioate
  参考文献：
  名称：

  Visible-Light-Promoted Xanthate-Transfer Cyclization Reactions of Unactivated Olefins under Photocatalyst- and Additive-Free Conditions

  摘要：

  DOI：

  10.1021/acs.joc.2c02113
• 作为产物：
  描述：

  4-戊烯酸 、 异丙胺 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 N-propan-2-ylpent-4-enamide
  参考文献：
  名称：

  Visible-Light-Promoted Xanthate-Transfer Cyclization Reactions of Unactivated Olefins under Photocatalyst- and Additive-Free Conditions

  摘要：

  DOI：

  10.1021/acs.joc.2c02113

文献信息

• Intramolecular electrophilic cyclization of functional derivatives of unsaturated compounds: II. Synthesis and transformation of N-{(2Z)-5-[(arylsulfanyl)methyl]dihydrofuran-2(3H)-ylidene}-N-alkyl(aryl)aminium perchlorates
  作者：A. I. Vas’kevich、N. M. Tsizorik、E. B. Rusanov、V. I. Staninets、M. V. Vovk

  DOI：10.1134/s1070428012020078

  日期：2012.2

  N-Alkyl(aryl)amides of allylacetic acid when reacting with arylsulfenyl chlorides in acetic acid in the presence of lithium perchlorate undergo a selective cyclization to form N-(2Z)-5-[(arylsulfanyl)methyl] dihydrofuran-2(3H)-ylidene}-N-alkyl-(aryl)aminium perchlorates. Treating of the latter with sodium acetate leads to the formation of the corresponding 5-[(arylsulfanyl)methyl]lactones, and with

  在高氯酸锂存在下与乙酸中的芳基亚硫酰氯反应时，烯丙酸的N-烷基（芳基）酰胺经过选择性环化反应生成N -（2 Z）-5-[（芳基硫烷基）甲基]二氢呋喃-2（ 3 H）-亚烷基} -N-烷基-（芳基）高氯酸铵。后者用乙酸钠处理导致形成相应的5-[（（芳基硫烷基）甲基]内酯，并用乙酸乙酯处理成5-[（（芳基硫烷基）甲基] -2-亚氨基内酯。与仲环烷基胺在水的存在下反应，发生氨基转移和四氢呋喃开环，得到5-芳基硫烷基-4-羟基戊酸酰胺。
• Cyclic peptide epitopes and small-molecule mimics for inducing autophagy
  申请人：TRUSTEES OF TUFTS COLLEGE

  公开号：US10993983B2

  公开（公告）日：2021-05-04

  Disclosed herein are cyclic peptides that induce cellular autophagy and have significant cell penetration activity. Methods for inducing autophagy and thereby treating various diseases and conditions associated with impaired autophagy are provided.

  本文公开了诱导细胞自噬并具有显著细胞渗透活性的环肽。本文提供了诱导自噬从而治疗与自噬受损有关的各种疾病和病症的方法。
• A HIGH-TEMPERATURE HIGH-PRESSURE (HTHP) STABLE SYNTHETIC POLYMER FOR WATER BASED OIL-WELL SERVICING FLUIDS
  申请人：ISP Investments Inc.

  公开号：EP3013875A1

  公开（公告）日：2016-05-04
• MODIFIED POLYSACCHARIDES FOR CONJUGATE VACCINES
  申请人：Michon Francis

  公开号：US20100189740A1

  公开（公告）日：2010-07-29

  The present invention relates to methods of manufacture of immunogenic glycoconjugates, in particular for use in pharmaceutical compositions for inducing a therapeutic immune response in a subject. The immunogenic glycoconjugates of the invention comprise one or more oligosaccharides or polysaccharides that are conjugated to one or more carrier proteins via an active aldehyde group. Accordingly, the invention provides methods of making (i) unsaturated microbial N-acyl derivative oligosaccharides or polysaccharides; (ii) novel conjugates of unsaturated N-acyl derivatives; and (iii) glycoconjugate compositions comprising conjugate molecules of fragments of microbial unsaturated N-acyl derivatives that serve as a covalent linker to one or more proteins. The invention further encompasses the use of the immunogenic glycoconjugates pharmaceutical compositions for the prevention or treatment of an infectious disease.
• Modified Polysaccharides for Conjugate Vaccines
  申请人：Baxter International Inc.

  公开号：US20130197203A1

  公开（公告）日：2013-08-01

  The present invention relates to methods of manufacture of immunogenic glycoconjugates, in particular for use in pharmaceutical compositions for inducing a therapeutic immune response in a subject. The immunogenic glycoconjugates of the invention comprise one or more oligosaccharides or polysaccharides that are conjugated to one or more carrier proteins via an active aldehyde group. Accordingly, the invention provides methods of making (i) unsaturated microbial N-acyl derivative oligosaccharides or polysaccharides; (ii) novel conjugates of unsaturated N-acyl derivatives; and (iii) glycoconjugate compositions comprising conjugate molecules of fragments of microbial unsaturated N-acyl derivatives that serve as a covalent linker to one or more proteins. The invention further encompasses the use of the immunogenic glycoconjugates pharmaceutical compositions for the prevention or treatment of an infectious disease.