(2R)-2-azaniumyl-3-[4-(4-hydroxyphenoxy)-3-iodophenyl]propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-azaniumyl-3-[4-(4-hydroxyphenoxy)-3-iodophenyl]propanoate
• 化学式: C15H14INO4
• 分子量: 399.18
• InChiKey: SXQVOFSDWXYIRP-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Liquid reagent of thyroid hormone-immobilized carrier and use thereof
  申请人：Arkray, Inc.

  公开号：EP2485053A1

  公开（公告）日：2012-08-08

  A liquid reagent of a stabilized thyroid hormone-immobilized carrier, by which a thyroid hormone can be measured easily in a short time and at low cost, is provided. The liquid reagent of a thyroid hormone-immobilized carrier according to the present invention includes: a thyroid hormone-immobilized carrier; and a solvent, and the pH of the solvent containing the thyroid hormone-immobilized carrier is in the range 8.7 to 11.5. The detection of a thyroid hormone using the liquid reagent of the present invention can be carried out by competitively binding a thyroid hormone in a sample and the thyroid hormone-immobilized carrier in the liquid reagent with an anti-thyroid hormone antibody and detecting a composite of the thyroid hormone-immobilized carrier and the anti-thyroid hormone antibody. According to the present invention, the thyroid hormone-immobilized carrier can be stabilized by setting the pH of the liquid reagent in the predetermined range, so that the liquid reagent can be stored for a long period of time. Moreover, it is not necessary to prepare the thyroid hormone-immobilized carrier every time the measurement is to be carried out, so that the thyroid hormone can be measured easily in a short time and at low cost.

  本发明提供了一种稳定甲状腺激素固定化载体的液体试剂，通过该试剂可以在短时间内以低成本方便地测量甲状腺激素。根据本发明，甲状腺激素固定化载体的液体试剂包括：甲状腺激素固定化载体；溶剂，含有甲状腺激素固定化载体的溶剂的 pH 值在 8.7 至 11.5 之间。使用本发明的液体试剂检测甲状腺激素，可以通过用抗甲状腺激素抗体竞争性结合样品中的甲状腺激素和液体试剂中的甲状腺激素固定化载体，并检测甲状腺激素固定化载体和抗甲状腺激素抗体的复合体。根据本发明，可以通过将液体试剂的 pH 值设定在预定范围内来稳定甲状腺激素固定化载体，从而使液体试剂可以长期保存。此外，无需每次测量时都制备甲状腺激素固定载体，因此可在短时间内以低成本轻松测量甲状腺激素。
• Liquid Reagent of Thyroid Hormone-Immobilized Carrier and Use Thereof
  申请人：Onuma Naotsugu

  公开号：US20120202230A1

  公开（公告）日：2012-08-09

  A liquid reagent of a stabilized thyroid hormone-immobilized carrier, by which a thyroid hormone can be measured easily in a short time and at low cost, is provided. The liquid reagent of a thyroid hormone-immobilized carrier according to the present invention includes: a thyroid hormone-immobilized carrier; and a solvent, and a pH of the solvent containing the thyroid hormone-immobilized carrier is in a range from 8.7 to 11.5. The detection of a thyroid hormone using the liquid reagent of the present invention can be carried out by competitively binding a thyroid hormone in a sample and the thyroid hormone-immobilized carrier in the liquid reagent with an anti-thyroid hormone antibody and detecting a composite of the thyroid hormone-immobilized carrier and the anti-thyroid hormone antibody.
• SERUM-FREE CULTURE MEDIUM FOR LIMBAL STEM CELLS AND CULTURE METHOD THEREOF
  申请人：Zhongshan Ophthalmic Center, Sun Yat-Sen University

  公开号：US20190345442A1

  公开（公告）日：2019-11-14

  A serum-free culture medium for limbal stem cells and a culture method thereof, wherein the serum-free culture medium includes a basic medium and supplements; wherein the supplements include: human recombinant EGF, insulin, 3,3′,5-triiodo-L-thyronine, hydrocortisone, forskolin, manganese sulfate monohydrate, sodium selenite, sodium metasilicate, ammonium metavanadate, nickel chloride hexahydrate, stannous chloride dihydrate, ethanolamine, O-phosphorylethanolamine, ammonium molybdate tetrahydrate, 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid, vitamin C, bovine serum albumin, lipid concentrate and serum substitute. The serum-free culture medium according to the present invention is free of fetal bovine serum and any animal-derived ingredient, can provide necessary adequate nutrition and good environment for cell growth and proliferation, effectively replaces the role of serum, realizes favorable cell growth, improves the cell purity and stability, provides quick and stable cell sources for researches on the mechanism of limbal stem cell specificity and transplantation therapy, and has broad clinical application prospects.
• US5767227A
  申请人：——

  公开号：US5767227A

  公开（公告）日：1998-06-16
• US5910569A
  申请人：——

  公开号：US5910569A

  公开（公告）日：1999-06-08