7-chloro-4-hydroxy-1-methyl-5-phenyl-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-one | 65267-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 7-chloro-4-hydroxy-1-methyl-5-phenyl-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-one
• 英文别名: 7-Chloro-1,3,4,5-tetrahydro-4-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one；7-chloro-4-hydroxy-1-methyl-5-phenyl-3,5-dihydro-1,4-benzodiazepin-2-one
• CAS: 65267-29-0
• 化学式: C₁₆H₁₅ClN₂O₂
• 分子量: 302.76
• InChiKey: NWKPFLVHSRDOHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-chloro-1-methyl-4-oxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one 、 phenylmagnesium bromide 生成 7-chloro-4-hydroxy-1-methyl-5-phenyl-1,3,4,5-tetrahydro-benzo[e][1,4]diazepin-2-one
  参考文献：
  名称：

  NEDENSKOV P.; MANDRUP M., ACTA CHEM. SCAND. , 1977, B 31, NO 8, 701-706

  摘要：

  DOI：

文献信息

• Inhibition of respiratory complex III by ligands that interact with a regulatory switch
  申请人：The Regents of the University of California

  公开号：US11058645B2

  公开（公告）日：2021-07-13

  The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.

  本发明提供了抑制细胞中呼吸复合体 III 的方法。本发明还提供了治疗受试者癌症的方法。
• INHIBITION OF RESPIRATORY COMPLEX III BY LIGANDS THAT INTERACT WITH A REGULATORY SWITCH
  申请人：The Regents of the University of California

  公开号：US20210309617A1

  公开（公告）日：2021-10-07

  The present invention provides methods for inhibiting respiratory complex III in a cell. The present invention also provides methods for treating cancer in a subject.