7-benzyloxy-8-methoxy-1-oxo-6-{3-[1,4,5,6,8-pentamethoxy-3-(triethylsilanyloxy)naphthalen-2-ylmethyl]-4,5-dihydroisoxazol-5-yl}-1H-isochromene-3-carboxylic acid methyl ester | 1315507-90-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异香豆素及其衍生物
• 英文名称: 7-benzyloxy-8-methoxy-1-oxo-6-{3-[1,4,5,6,8-pentamethoxy-3-(triethylsilanyloxy)naphthalen-2-ylmethyl]-4,5-dihydroisoxazol-5-yl}-1H-isochromene-3-carboxylic acid methyl ester
• 英文别名: Methyl 8-methoxy-1-oxo-6-[3-[(1,4,5,6,8-pentamethoxy-3-triethylsilyloxynaphthalen-2-yl)methyl]-4,5-dihydro-1,2-oxazol-5-yl]-7-phenylmethoxyisochromene-3-carboxylate
• CAS: 1315507-90-4
• 化学式: C₄₄H₅₁NO₁₃Si
• 分子量: 829.973
• InChiKey: FOLSAARMBTXAQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.81
• 重原子数：
  59
• 可旋转键数：
  19
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  148
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  7-benzyloxy-8-methoxy-1-oxo-6-{3-[1,4,5,6,8-pentamethoxy-3-(triethylsilanyloxy)naphthalen-2-ylmethyl]-4,5-dihydroisoxazol-5-yl}-1H-isochromene-3-carboxylic acid methyl ester 在 盐酸 、 氢气 、 硼酸 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 10.0h， 生成 7-benzyloxy-6-[1-hydroxy-4-(3-hydroxy-1,4,5,6,8-pentamethoxynaphthalen-2-yl)-3-oxo-butyl]-8-methoxy-1-oxo-1H-isochromene-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Alternative Spiroketalization Methods toward Purpuromycin: A Diketone Approach To Prevent Benzofuran Formation

  摘要：

  The central portion of purpuromycin has been assembled via a classical spiroketalization reaction. Key to promoting this reaction mode versus benzofuran formation was the oxidation state of the spiroketal core. With a higher oxidation state, even the electron-deficient isocoumarin found in purpuromycin could be employed directly in the spiroketalization. The two halves of the spiroketalization precursor were joined via a nitrile oxide/styrene 1,3-dipolar cycloaddition. A very mild selenium dioxide oxidation was used to introduce the required oxidation state of the spiroketal core.

  DOI：

  10.1021/jo200399z
• 作为产物：
  描述：

  triethyl-[1,4,5,7,8-pentamethoxy-3-(2-nitro-ethyl)-naphthalen-2-yloxy]-silane 、 7-benzyloxy-8-methoxy-1-oxo-6-vinyl-1H-isochromene-3-carboxylic acid methyl ester 在 异氰酸苯酯 、 三乙胺 作用下， 以 苯 为溶剂， 反应 40.0h， 以70%的产率得到7-benzyloxy-8-methoxy-1-oxo-6-{3-[1,4,5,6,8-pentamethoxy-3-(triethylsilanyloxy)naphthalen-2-ylmethyl]-4,5-dihydroisoxazol-5-yl}-1H-isochromene-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Alternative Spiroketalization Methods toward Purpuromycin: A Diketone Approach To Prevent Benzofuran Formation

  摘要：

  The central portion of purpuromycin has been assembled via a classical spiroketalization reaction. Key to promoting this reaction mode versus benzofuran formation was the oxidation state of the spiroketal core. With a higher oxidation state, even the electron-deficient isocoumarin found in purpuromycin could be employed directly in the spiroketalization. The two halves of the spiroketalization precursor were joined via a nitrile oxide/styrene 1,3-dipolar cycloaddition. A very mild selenium dioxide oxidation was used to introduce the required oxidation state of the spiroketal core.

  DOI：

  10.1021/jo200399z

文献信息

• Alternative Spiroketalization Methods toward Purpuromycin: A Diketone Approach To Prevent Benzofuran Formation
  作者：Andrew N. Lowell、Michael W. Fennie、Marisa C. Kozlowski

  DOI：10.1021/jo200399z

  日期：2011.8.19

  The central portion of purpuromycin has been assembled via a classical spiroketalization reaction. Key to promoting this reaction mode versus benzofuran formation was the oxidation state of the spiroketal core. With a higher oxidation state, even the electron-deficient isocoumarin found in purpuromycin could be employed directly in the spiroketalization. The two halves of the spiroketalization precursor were joined via a nitrile oxide/styrene 1,3-dipolar cycloaddition. A very mild selenium dioxide oxidation was used to introduce the required oxidation state of the spiroketal core.