N²N⁶-bis-trifluoroacetyl-DL-lysine | 7573-81-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N²N⁶-bis-trifluoroacetyl-DL-lysine
• 英文别名: N²N⁶-Bis-trifluoracetyl-DL-lysin；2,6-Bis[(2,2,2-trifluoroacetyl)amino]hexanoic acid
• CAS: 7573-81-1
• 化学式: C₁₀H₁₂F₆N₂O₄
• 分子量: 338.207
• InChiKey: CMASOZDUMXUWEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N²N⁶-bis-trifluoroacetyl-DL-lysine 、 乙醇 、 盐酸 生成 ethyl N2,N6-bis(trifluoroacetyl)lysinate
  参考文献：
  名称：

  SAPOROVSKAYA, M. B.;VOLKOVA, L. M.;PAVLOV, V. A., ZH. ANAL. XIMII, 44,(1989) N, S. 525-528

  摘要：

  DOI：
• 作为产物：
  描述：

  三氟乙酸酐 生成 N²N⁶-bis-trifluoroacetyl-DL-lysine
  参考文献：
  名称：

  SAPOROVSKAYA, M. B.;VOLKOVA, L. M.;PAVLOV, V. A., ZH. ANAL. XIMII, 44,(1989) N, S. 525-528

  摘要：

  DOI：

文献信息

• MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US20190077746A1

  公开（公告）日：2019-03-14

  Micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups which are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. Monomers bearing carboxyl groups and/or pro-carboxyl groups are used to produce an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified. The carboxyl groups and/or pro-carboxyl groups are converted into active esters. A reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms is used to form amide bonds and obtain a covalently modified surface layer.

  微纳米材料，通过用亲水材料共价修饰微/纳米材料表面获得的产品，以及制备这些产品的方法。表面上的微/纳米材料具有羧基或/和前羧基，这些羧基或前羧基被转化为它们的活性酯。通过在表面上的活性酯和修饰剂之间形成酰胺键，共价修饰的产品；其中修饰剂是带有一次和/或二次脂肪胺基的亲水化合物和/或亲水性聚合物。使用带有羧基和/或前羧基的单体来产生足够数量的羧基和/或前羧基，以便在待修饰的聚合物材料表面上形成。将羧基和/或前羧基转化为活性酯。使用合理大小的带有一次和/或二次胺基、带有带电离子和亲水性线性间隔臂的修饰剂来形成酰胺键，并获得共价修饰的表面层。
• NUCLEOBASE-FUNCTIONALIZED CONFORMATIONALLY RESTRICTED NUCLEOTIDES AND OLIGONUCLEOTIDES FOR TARGETING OF NUCLEIC ACIDS
  申请人：Hrdlicka Patrick J.

  公开号：US20120295862A1

  公开（公告）日：2012-11-22

  Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.

  本文披露了涉及C5-官能化核酸的实施例，可用于检测核酸中的目标。特定实施例披露了制备这些化合物的方法，其中化合物可以通过中间体与连接剂的偶联形成。某些实施例披露了使用这些化合物检测单核苷酸多态性，并将其与未经修饰的核酸互补物相比增加了热亲和力。此外，披露的化合物可以减少核酸的酶降解。
• Micro/nano materials, products obtained by covalently modifying surface of micro/nano materials with hydrophilic materials, and method for making same
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US10385013B2

  公开（公告）日：2019-08-20

  Micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups which are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. Monomers bearing carboxyl groups and/or pro-carboxyl groups are used to produce an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified. The carboxyl groups and/or pro-carboxyl groups are converted into active esters. A reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms is used to form amide bonds and obtain a covalently modified surface layer.

  微纳米材料、通过亲水材料共价改性微/纳米材料表面而获得的产品以及制造方法。微米/纳米材料表面具有羧基或/和原羧基，这些羧基可转化为活性酯。通过在表面上的活性酯和改性剂之间形成酰胺键，对产品进行共价改性；其中，改性剂是亲水性化合物和/或亲水性聚合物，带有伯胺和/或仲脂族胺。含有羧基和/或原羧基的单体用于在待改性聚合物材料表面产生足够数量的羧基和/或原羧基。羧基和/或原羧基被转化为活性酯。使用含有伯胺和/或仲胺、齐聚物和亲水性线性间隔臂的合理大小的改性剂来形成酰胺键，从而获得共价改性表层。
• Weygand; Geiger, Chemische Berichte, 1956, vol. 89, p. 647,650
  作者：Weygand、Geiger

  DOI：——

  日期：——
• NUCLEOBASE-FUNCTIONALIZED CONFORMATIONALLY RESTRICTED NUCLEOTIDES AND OLIGONUCLEOTIDES FOR TARGETING NUCLEIC ACIDS
  申请人：Hrdlicka Patrick Jerzy

  公开号：US20130337581A1

  公开（公告）日：2013-12-19

  Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.