8-(2-Isopropoxyethyl)-3-(4-methoxy-2,6-dimethylphenyl)-2,5-dimethyl-7-propyl-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine | 344291-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 8-(2-Isopropoxyethyl)-3-(4-methoxy-2,6-dimethylphenyl)-2,5-dimethyl-7-propyl-8H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine
• 英文别名: 10-(4-Methoxy-2,6-dimethylphenyl)-7,11-dimethyl-3-(2-propan-2-yloxyethyl)-4-propyl-1,3,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
• CAS: 344291-35-6
• 化学式: C₂₇H₃₆N₄O₂
• 分子量: 448.608
• InChiKey: LZDMLVGNCHJCKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  53.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 1-Methylcarbapenem derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20040014962A1

  公开（公告）日：2004-01-22

  1-Methylcarbapenem compounds having antibacterial activity, pharmacologically acceptable esters or salts thereof and pharmaceutical compositions (particularly antibacterial agents) containing them as an active ingredient are described. In addition, the invention includes the use of these compounds, ester derivatives or salts for the manufacture of pharmaceutical compositions, or a method for the prevention or treatment of diseases (particularly bacterial infections) by administering a pharmacologically effective amount of the compounds, ester derivatives or salts to warm-blooded animals (particularly human beings).

  描述了具有抗菌活性的1-甲基碳青霉烯化合物、它们的药物可接受的酯或盐，以及含有它们作为活性成分的药物组合物（特别是抗菌剂）。此外，发明包括这些化合物、酯衍生物或盐用于制造药物组合物，或通过向温血动物（特别是人类）投给药物有效量的这些化合物、酯衍生物或盐，用于预防或治疗疾病（特别是细菌感染）的方法。
• Fused heterotricyclic compounds, process for preparing the compounds and drugs containing the same
  申请人：——

  公开号：US20030078277A1

  公开（公告）日：2003-04-24

  The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. 1 Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR 1 R 2 ) m — (wherein R 1 and R 2 are the same as or different from each other and each represents a C 1-6 alkyl group etc.), —NR 3 — (wherein R 3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR 6 R 7 ) p — (wherein R 6 and R 7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C 1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C 1-6 alkyl group etc.; and the partial structure means a single or double bond.

  本发明提供了一种具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新化合物。即提供了由以下公式表示的化合物，其药理学上可接受的盐或水合物。其中A、B和D相互相同或不同，每个代表以下公式表示的基团：—(CR1R2)m—（其中R1和R2相互相同或不同，每个代表C1-6烷基等），—NR3—（其中R3代表氢等）等；E和G相互相同或不同，每个代表以下公式表示的基团：—(CR6R7)p—（其中R6和R7相互相同或不同，每个代表氢等；p代表0、1或2的整数）；J代表一个碳原子或氮原子，每个都被C1-6烷基等可选择地取代的卤素原子等取代；K和L相互相同或不同，每个代表碳原子或氮原子；M代表氢、卤素原子、可选择地取代的C1-6烷基等；部分结构表示单键或双键。
• Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it
  申请人：Hibi Shigeki

  公开号：US20050004159A1

  公开（公告）日：2005-01-06

  The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR 1 R 2 ) m — (wherein R 1 and R 2 are the same as or different from each other and each represents a C 1-6 alkyl group etc.), —NR 3 — (wherein R 3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR 6 R 7 ) p — (wherein R 6 and R 7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C 1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C 1-6 alkyl group etc.; and the partial structure means a single or double bond.

  本发明提供了一种具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新化合物。即，本发明提供了由以下式表示的化合物，其药学上可接受的盐或水合物。其中，A、B和D相同或不同，每个代表由公式—（CR1R2）m—（其中R1和R2相同或不同，每个代表C1-6烷基等）、—NR3—（其中R3表示氢等）等表示的基团；E和G相同或不同，每个代表由公式—（CR6R7）p—（其中R6和R7相同或不同，每个代表氢等；p表示0、1或2的整数）表示的基团；J代表一个碳原子或氮原子，每个用C1-6烷基取代，可选择用卤原子等取代；K和L相同或不同，每个代表碳原子或氮原子；M表示氢、卤原子、可选择用取代的C1-6烷基等取代；而部分结构表示单键或双键。
• FUSED HETEROTRICYCLIC COMPOUNDS, PROCESS FOR PREPARING THE COMPOUNDS AND DRUGS CONTAINING THE SAME
  申请人：Eisai Co., Ltd.

  公开号：EP1238979A1

  公开（公告）日：2002-09-11

  The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula - (CR1R2)m- (wherein R1 and R2 are the same as or different from each other and each represents a C1-6 alkyl group etc.), -NR3- (wherein R3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula - (CR6R7)p- (wherein R6 and R7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C1-6 alkyl group etc.; and the partial structure ----- means a single or double bond.

  本发明提供了一种新型化合物，它具有优异的促肾上腺皮质激素释放因子受体拮抗活性。也就是说，本发明提供了由下式表示的化合物、其药理学上可接受的盐或其水合物。 其中 A、B 和 D 彼此相同或不同，且各自代表由式 - (CR1R2)m- （其中 R1 和 R2 彼此相同或不同，且各自代表 C1-6 烷基等）、-NR3-（其中 R3 代表氢等）等表示的基团；E 和 G 彼此相同或不同，且各自代表由式 - (CR6R7)p- （其中 R6 和 R7 彼此相同或不同，且各自代表氢等）表示的基团。其中 R6 和 R7 彼此相同或不同，各自代表氢等；p 代表 0、1 或 2 的整数）；J 代表碳原子或氮原子，各自被 C1-6 烷基任选取代，并被卤素原子等取代；K 和 L 彼此相同或不同，各自代表碳原子或氮原子；M 指氢、卤素原子、任选取代的 C1-6 烷基等；部分结构 ----- 指单键或双键。
• 1-METHYLCARBAPENEM DERIVATIVES
  申请人：Sankyo Company, Limited

  公开号：EP1340757A1

  公开（公告）日：2003-09-03

  The present invention relates to 1-methylcarbapenem compounds having excellent antibacterial activity, pharmacologically acceptable ester derivatives thereof, pharmacologically acceptable salts thereof, pharmaceutical compositions (particularly antibacterial agents) containing them as active ingredient, use of the compounds, ester derivatives or salts thereof for preparing such pharmaceutical compositions and a method of preventing or treating diseases (particularly bacterial infections) in which a pharmacologically effective amount of the compound, ester derivative or salt is administered to a warm-blooded animal (particularly a human being). The 1-methylcarbapenem compounds of the present invention are represented by the general formula (I): wherein: R1 is a group represented by the formula COOR3 (wherein R3 represents a hydrogen atom, a C1-C6 alkyl group or the like), a group represented by the formula CONR4R5 (wherein R4 and R5 each independently represent a hydrogen atom, a C1-C6 alkyl group which may be substituted or the like), a cyano group, a group represented by the formula CH2OR6 (wherein R6 represents a hydrogen atom, a C1-C6 alkyl group or the like) or a group represented by the formula CH2NR7R8 (wherein R7 represents a hydrogen atom, a C1-C6 alkyl group or the like, and R8 represents a hydrogen atom, a C1-C6 alkyl group, a C1-C6 alkanoyl group, a C1- C6 alkoxycarbonyl group or the like); R2 represents a hydrogen atom or a C1-C6 alkyl group; n represents 1, 2 or 3; and X represents a sulfur atom or an oxygen atom.

  本发明涉及具有优异抗菌活性的1-甲基碳青霉烯类化合物、其药理学上可接受的酯衍生物、其药理学上可接受的盐、含有它们作为活性成分的药物组合物（特别是抗菌剂）、使用这些化合物、酯衍生物或其盐制备这种药物组合物以及一种预防或治疗疾病（特别是细菌感染）的方法，在这种方法中，药理学上有效量的化合物、酯衍生物或盐被施用于温血动物（特别是人）。 本发明的 1-甲基碳青霉烯化合物由通式 (I) 表示： 其中 R1 是由式 COOR3 代表的基团（其中 R3 代表氢原子、C1-C6 烷基或类似基团）、由式 CONR4R5 代表的基团（其中 R4 和 R5 各自独立地代表氢原子、可被取代的 C1-C6 烷基或类似基团）、氰基、由式 CH2OR6 代表的基团（其中 R6 代表氢原子、C1-C6 烷基或类似基团）或由式 CH2NR7R8 代表的基团（其中 R7 代表氢原子、C1-C6 烷基或类似基团，R8 代表氢原子、C1-C6 烷基、C1-C6 烷酰基、C1-C6 烷氧羰基或类似基团）； R2 代表氢原子或 C1-C6 烷基； n 代表 1、2 或 3；以及 X 代表硫原子或氧原子。