2-Dimethylamino-chinolin | 33333-65-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Dimethylamino-chinolin
• 英文别名: indol-2-yl-dimethyl-amine；N,N-dimethyl-1H-indol-2-amine
• CAS: 33333-65-2
• 化学式: C₁₀H₁₂N₂
• 分子量: 160.219
• InChiKey: YFKNCTBAPAZLON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Combinations of substituted azetidinones and CB1 antagonists
  申请人：Veltri P. Enrico

  公开号：US20060069080A1

  公开（公告）日：2006-03-30

  The present invention provides compositions, therapeutic combinations and methods including: (a) at least one selective CB 1 antagonist; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity, metabolic syndrome and lowering plasma levels of sterols or 5α-stanols.

  本发明提供了包括以下内容的组合物、治疗组合和方法：(a)至少一种选择性CB1拮抗剂；和(b)至少一种取代的氮杂环丁烷或取代的β-内酰胺甾醇吸收抑制剂，可用于治疗血管疾病、糖尿病、肥胖、代谢综合征以及降低血浆中的甾醇或5α-甾烷醇水平。
• NOVEL INDOLIC DERIVATIVES, THEIR PREPARATION PROCESSES AND THEIR USES IN PARTICULAR AS ANTIBACTERIALS
  申请人：Denis Jean-Noel Marie Leon

  公开号：US20100144726A1

  公开（公告）日：2010-06-10

  The invention relates to the use of at least one compound of the formula (I), in which R and R 3 are particularly a hydrogen atom, R 1 is particularly a hydrogen atom or a methyl, ethyl or isobutyl mi group, R 4 , R 5 , R 6 and R 7 are independently a hydrogen atony, an alkoxyl group with 1 to 7 carbon atoms or a halogen atom, R 2 is a hydrogen atom, an O − group or an OH group, B is an N-GP 1 or NR c , group, GP 1 being a Boc or Cbz group, and R c is a hydrogen atom or a methyl or t-butyl group, for preparing a drug for treating conditions associated with bacterial infections, in particular for treating bacterial diseases.

  该发明涉及使用至少一种具有以下式（I）的化合物，其中R和R3特别是氢原子，R1特别是氢原子或甲基、乙基或异丁基mi基团，R4、R5、R6和R7独立地是氢原子、具有1至7个碳原子的烷氧基团或卤原子，R2是氢原子、O−基团或OH基团，B是N-GP1或NRc基团，GP1是Boc或Cbz基团，Rc是氢原子或甲基或叔丁基基团，用于制备用于治疗与细菌感染相关的疾病症状的药物，特别是用于治疗细菌性疾病。
• [EN] PROCESS FOR PRODUCING AROMATIC COMPOUNDS BY FRIEDEL-CRAFTS REACTION<br/>[FR] PROCEDE DE PRODUCTION DE COMPOSES AROMATIQUES PAR REACTION DE FRIEDEL-CRAFTS
  申请人：SHOWA DENKO KK

  公开号：WO2003101925A1

  公开（公告）日：2003-12-11

  There is provided a process for producing an aromatic compound by Friedel-Crafts reaction product, which comprises reacting an aromatic compound with an ester compound in the presence of a heteropolyacid-containing solid acid catalyst.

  提供一种通过Friedel-Crafts反应产生芳香化合物的方法，包括在含有杂多酸的固体酸催化剂的存在下，将芳香化合物与酯化合物反应。
• Process for producing aromatic compounds by friedel-crafts reaction
  申请人：Okuhara Toshio

  公开号：US20050222457A1

  公开（公告）日：2005-10-06

  There is provided a process for producing an aromatic compound by Friedel-Crafts reaction product, which comprises reacting an aromatic compound with an ester compound in the presence of a heteropolyacid-containing solid acid catalyst.

  提供一种通过Friedel-Crafts反应产生芳香族化合物的方法，其包括在含有杂多酸的固体酸催化剂的存在下，将芳香族化合物与酯化合物反应。
• Curable composition
  申请人：KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP0300146A1

  公开（公告）日：1989-01-25

  A curable composition. The composition contain (A) a copolymer that has silicon-containing functional groups capable of crosslinking by forming siloxane bonds and whose molecular chain consists substantially of: (1) an alkyl acrylate ester monomeric unit and/or an alkyl methacrylate ester monomeric unit, the alkyl of each being 1 to 8 carbon atoms; and (2) an alkyl acrylate ester monomeric unit and/or an alkyl methacrylate ester monomeric unit, the alkyl of each being at least 10 carbon atoms; (B) an oxyalkylene polymer having silicon-­containing functional groups that are capable of crosslinking by forming siloxane bonds; and (C) at least one compound selected from (i) a hydrolyzable organic silane monomer represented by the formula (I):       R¹4-nSiXn wherein X is a hydrolyzable group, R¹ is a monovalent organic group having 1 to 18 carbon atoms, n is an integer of 1 to 4, and each R¹ or X can be the same or different when two or more R¹ or X groups are attached, (ii) a partial hydrolysis condensate of the organic silane monomer represented by the formula (I), and (iii) an orthoorganic acid ester represented by the formula (II):       R²C(OR³)₃ wherein R² is hydrogen or methyl, R³ is a monovalent organic group having 1 to 8 carbon atoms, and the three R³ groups do not need to be the same.

  一种可固化组合物。该组合物包含 (A) 具有含硅官能团的共聚物，该官能团能通过形成硅氧烷键而交联，其分子链主要由以下部分组成： (1) 丙烯酸烷基酯单体单元和/或甲基丙烯酸烷基酯单体单元，每个单体的烷基为 1 至 8 个碳原子；和 (2) 一个丙烯酸烷基酯单体单元和/或一个甲基丙烯酸烷基酯单体单元，每个单体的烷基至少为 10 个碳原子； (B) 含硅官能团的氧亚链聚合物，该官能团可通过形成硅氧烷键而交联；以及 (C) 至少一种选自以下物质的化合物 (i) 由式 (I) 表示的可水解有机硅烷单体： R¹4-nSiXn 其中 X 是可水解基团，R¹ 是具有 1 至 18 个碳原子的一价有机基团，n 是 1 至 4 的整数，当连接两个或两个以上 R¹ 或 X 基团时，每个 R¹ 或 X 可以相同或不同、 (ii) 式（I）代表的有机硅烷单体的部分水解缩合物，和 (iii) 式(II)代表的原有机酸酯： R²C(OR³)₃ 其中 R² 是氢或甲基，R³ 是具有 1 至 8 个碳原子的一价有机基团，三个 R³ 基团不必相同。